Studies

Psychiatry

Iolascon G, Gimigliano R, Bianco M et al. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. J Nutr Health Aging. 2017;21(5):527-538.


Canhada S, Castro K, Perry IS et al. Omega-3 fatty acids' supplementation in Alzheimer's disease: A systematic review. Nutr Neurosci. 2017 May 3:1-10.


Cai HL, Jiang P, Tan QY et al. Therapeutic efficacy of atypical antipsychotic drugs by targeting multiple stress-related metabolic pathways. Transl Psychiatry. 2017 May 16;7(5):e1130.


Mitra S, Natarajan R, Ziedonis D et al. Antioxidant and anti-inflammatory nutrient status, supplementation, and mechanisms in patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2017 May 9.


Borsini A, Alboni S, Horowitz MA et al. Rescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants. Brain Behav Immun. 2017 May 18.


Andruchow ND, Konishi K, Shatenstein B et al. A Lower Ratio of Omega-6 to Omega-3 Fatty Acids Predicts Better Hippocampus-Dependent Spatial Memory and Cognitive Status in Older Adults. Neuropsychology. 2017 Apr 10.


Deyama S, Ishikawa Y, Yoshikawa K et al. Resolvin D1 and D2 reverse lipopolysaccharide-induced depression-like behaviors through the mTORC1 signaling pathway. Int J Neuropsychopharmacol. 2017 Apr 13.


Lin PY, Chang CH, Chong MF et al. Polyunsaturated Fatty Acids in Perinatal Depression: A Systematic Review and Meta-analysis. Biol Psychiatry. 2017 Mar 9.


Messamore E, Almeida DM, Jandacek RJ, McNamara RK. Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application. Prog Lipid Res. 2017 Jan 6;66:1-13.


Tesei A, Crippa A, Ceccarelli SB, Mauri M, Molteni M, Agostoni C, Nobile M. The potential relevance of docosahexaenoic acid and eicosapentaenoic acid to the etiopathogenesis of childhood neuropsychiatric disorders. Eur Child Adolesc Psychiatry. 2016 Dec 17.


Woo J, Couturier J, Pindiprolu B, Picard L, Maertens C, Leclerc A, Findlay S, Johnson N, Grant C, Kimber M. Acceptability and tolerability of omega-3 fatty acids as adjunctive treatment for children and adolescents with eating disorders. Eat Disord. 2016 Dec 9:1-8.


Yanai H. Effects of N-3 Polyunsaturated Fatty Acids on Dementia. J Clin Med Res. 2017 Jan;9(1):1-9. Epub 2016 Nov 24. FULL TEXT


Kim SW, Jhon M, Kim JM et al. Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study. PLoS One. 2016 Mar 10;11(3):e0151417. doi: 10.1371/journal.pone.0151417. eCollection 2016. FULL TEXT


Messamore E, McNamara RK. Detection and treatment of omega-3 fatty acid deficiency in psychiatric practice: Rationale and implementation. Lipids Health Dis. 2016 Feb 10;15(1):25. doi: 10.1186/s12944-016-0196-5. FULL TEXT


Aukema HM, Winter T, Ravandi A, Dalvi S, Miller DW, Hatch GM5. Generation of Bioactive Oxylipins from Exogenously Added Arachidonic, Eicosapentaenoic and Docosahexaenoic Acid in Primary Human Brain Microvessel Endothelial Cells. Lipids. 2015 Oct 6.


Meyer BJ, Byrne MK, Collier C, Parletta N, Crawford D, Winberg PC, Webster D, Chapman K, Thomas G, Dally J, Batterham M, Farquhar I, Martin AM, Grant L. Baseline omega-3 index correlates with aggressive and attention deficit disorder behaviours in adult prisoners. PLoS One. 2015 Mar 20;10(3):e0120220. doi: 10.1371/journal.pone.0120220. FULL TEXT


Larrieu T, Hilal LM, Fourrier C, De Smedt-Peyrusse V, Sans N, Capuron L, Layé S.Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion. Transl Psychiatry. 2014 Sep 9;4:e437. FULL TEXT


Lotrich FE, Sears B, McNamara RK. Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. J Psychosom Res. 2013 Nov;75(5):475-83. FULL TEXT


Gómez-Pinilla F, Tyagi E. Diet and cognition: interplay between cell metabolism and neuronal plasticity. Curr Opin Clin Nutr Metab Care. 2013 Sep 25. FULL TEXT


Prior PL, Galduróz JC. (N-3) Fatty acids: molecular role and clinical uses in psychiatric disorders. Adv Nutr. 2012 May 1;3(3):257-65. FULL TEXT


Sinn N, Milte C, Howe PR. Oiling the brain: a review of randomized controlled trials of omega-3 fatty acids in psychopathology across the lifespan. Nutrients. 2010 Feb;2(2):128-70. FULL TEXT


Stahl LA, Begg DP, Weisinger RS, Sinclair AJ. The role of omega-3 fatty acids in mood disorders. Curr Opin Investig Drugs. 2008 Jan;9(1):57-64.


van Strater AC, Bouvy PF. Omega-3 fatty acids and mood disorders. Am J Psychiatry. 2006 Nov;163(11):2018; author reply 2018-9


Parker G, Gibson NA, Brotchie H, Heruc G, Rees AM, Hadzi-Pavlovic D. Omega-3 fatty acids and mood disorders. Am J Psychiatry. 2006 Jun;163(6):969-78. Review. Erratum in: Am J Psychiatry. 2006 Oct;163(10):1842.


Young C, Martin A. Omega-3 fatty acids in mood disorders: an overview. Rev Bras Psiquiatr. 2003 Sep;25(3):184-7. FULL TEXT


Zimmer L, Vancassel S, Cantagrel S, et al. The dopamine mesocorticolimbic pathway is affected by deficiency in n-3 polyunsaturated fatty acids. Am J Clin Nutr 2002;75:662-7. FULL TEXT

Attentionn Deficit Hyperactivity Disorder (ADHD

Adults

Children

Königs A, Kiliaan AJ. Critical appraisal of omega-3 fatty acids in attention-deficit/hyperactivity disorder treatment. Neuropsychiatr Dis Treat. 2016 Jul 26;12:1869-82. doi: 10.2147/NDT.S68652. eCollection 2016. FULL TEXT


Alfven G, Strandvik B. Anti-nociceptive fatty acid patterns differ in children with psychosomatic recurrent abdominal pain and healthy controls. Acta Paediatr. 2016 Feb 29. doi: 10.1111/apa.13381. [Epub ahead of print]


Bos DJ, Oranje B, Veerhoek ES, Van Diepen RM, Weusten JM, Demmelmair H, Koletzko B, de Sain-van der Velden MG, Eilander A, Hoeksma M, Durston S. Reduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attention Deficit/Hyperactivity Disorder. Neuropsychopharmacology. 2015 Sep;40(10):2298-306. FULL TEXT


Wu Q, Zhou T, Ma L, Yuan D, Peng Y. Protective effects of dietary supplementation with natural ω-3 polyunsaturated fatty acids on the visual acuity of school-age children with lower IQ or attention-deficit hyperactivity disorder. Nutrition. 2015 Jul-Aug;31(7-8):935-40.


Gow RV, Hibbeln JR, Parletta N. Current evidence and future directions for research with omega-3 fatty acids and attention deficit hyperactivity disorder. Curr Opin Clin Nutr Metab Care. 2015 Mar;18(2):133-8.


Milte CM, Parletta N, Buckley JD et al. Increased Erythrocyte Eicosapentaenoic Acid and Docosahexaenoic Acid Are Associated With Improved Attention and Behavior in Children With ADHD in a Randomized Controlled Three-Way Crossover Trial. J Atten Disord. 2013 Nov 8.


Richardson A. Background to the DOLAB Studies: Omega-3 and Child Behaviour and Learning. Omega-3 DHA and Children’s Behaviour and Learning: New Insights from the ‘DOLAB’ Studies. 4 September 2013 - The Royal College of Surgeons, London.


Dervola KS, Roberg BA, Wøien G et al. Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD. Behavioral and Brain Functions 2012;8(56):13 p. FULL TEXT


Bloch MH, Qawasmi A. Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 2011;50(10):991-1000. FULL TEXT


Gustafsson PA, Birberg-Thornberg U, Duchén K et al. EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD. Acta Paediatr. 2010 Oct;99(10):1540-1549.


Johnson M, Ostlund S, Fransson G, Kadesjö B, Gillberg C. Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. J Atten Disord. 2009 Mar;12(5):394-401.


Gow RV, Matsudaira T, Taylor E, Rubia K, Crawford M, Ghebremeskel K, Ibrahimovic A, Vallée-Tourangeau F, Williams LM, Sumich A. Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):151-6.


Sorgi PJ, Hallowell EM, Hutchins HL, Sears B. Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behaviour in children with attention deficit hyperactivity disorder. Nutr J. 2007;6:16. FULL TEXT


Burgess JR, Stevens L, Zhang W, Peck L. Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. Am J Clin Nutr. 2000;71(1 Suppl):327-30. FULL TEXT


Mitchell EA, Aman MG, Turbott SH, Manku M. Clinical characteristics and serum essential fatty acid levels in hyperactive children. Clin Pediatr (Philadelphia) 1987; 26(8): 406-11.

Bipolar disorder

Shakeri J, Khanegi M, Golshani S et al. Effects of Omega-3 Supplement in the Treatment of Patients with Bipolar I Disorder. Int J Prev Med. 2016 May 19;7:77. doi: 10.4103/2008-7802.182734. eCollection 2016. FULL TEXT


McNamara RK, Welge JA. Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. Bipolar Disord. 2016 Apr 18. doi: 10.1111/bdi.12386. [Epub ahead of print]


Rosenblat JD, Kakar R, Berk M et al. Anti-inflammatory agents in the treatment of bipolar depression: a systematic review and meta-analysis. Bipolar Disord. 2016 Mar 18. doi: 10.1111/bdi.12373. [Epub ahead of print]


Saunders EF, Reider A, Singh G, Gelenberg AJ, Rapoport SI. Low unesterified:esterified eicosapentaenoic acid (EPA) plasma concentration ratio is associated with bipolar disorder episodes, and omega-3 plasma concentrations are altered by treatment. Bipolar Disord. 2015 Nov;17(7):729-42.


McNamara RK, Jandacek R, Tso P, Blom TJ, Welge JA, Strawn JR, Adler CM, DelBello MP, Strakowski SM. First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: Dissociation from clinical response to lithium or quetiapine. Psychiatry Res. 2015 Oct 9. pii: S0165-1781(15)30394-2.


Clayton EH, Hanstock TL, Hirneth SJ et al. Reduced mania and depression in juvenile bipolar disorder associated with long-chain omega-3 polyunsaturated fatty acid supplementation. Eur J Clin Nutr. 2009 Aug;63(8):1037-1040.


Stoll AL, Severus WE, Freeman MP, Rueter S, Zboyan HA, Diamond E, Cress KK, Marangell LB. Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry. 1999;56:407-12. FULL TEXT

Borderline personality

Depression

Chang JP, Lin CY, Lin PY et al. Polyunsaturated fatty acids and inflammatory markers in major depressive episodes during pregnancy. Prog Neuropsychopharmacol Biol Psychiatry. 2017 May 20.


Ganança L, Galfalvy HC, Oquendo MA et al. Lipid correlates of antidepressant response to omega-3 polyunsaturated fatty acid supplementation: A pilot study. Prostaglandins Leukot Essent Fatty Acids. 2017 Apr;119:38-44.


Parekh A, Smeeth D, Milner Y, Thure S. The Role of Lipid Biomarkers in Major Depression. Healthcare (Basel). 2017 Feb 3;5(1).


Ravi S, Khalili H, Abbasian L, Arbabi M, Ghaeli P. Effect of Omega-3 Fatty Acids on Depressive Symptoms in HIV-Positive Individuals: A Randomized, Placebo-Controlled Clinical Trial. Ann Pharmacother. 2016 Jun 20. pii: 1060028016656017. [Epub ahead of print]


Roca M, Kohls E, Gili M et al. MooDFOOD Prevention Trial Investigators. Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial. BMC Psychiatry. 2016 Jun 8;16:192. doi: 10.1186/s12888-016-0900-z. FULL TEXT


Husted KS, Bouzinova EV. The importance of n-6/n-3 fatty acids ratio in the major depressive disorder. Medicina (Kaunas). 2016;52(3):139-47. doi: 10.1016/j.medici.2016.05.003. Epub 2016 May 30. FULL TEXT


Parletta N, Zarnowiecki D, Cho J et al. People with schizophrenia and depression have a low omega-3 index. Prostaglandins Leukot Essent Fatty Acids. 2016 Jul;110:42-7. doi: 10.1016/j.plefa.2016.05.007. Epub 2016 May 13.


Khajehnasiri F, Akhondzadeh S, Mortazavi SB et al. Are Supplementation of Omega-3 and Ascorbic Acid Effective in Reducing Oxidative Stress and Depression among Depressed Shift Workers? Int J Vitam Nutr Res. 2016 May 10:1-12. [Epub ahead of print]


Bigornia SJ, Harris WS, Falcón LM et al. The Omega-3 Index Is Inversely Associated with Depressive Symptoms among Individuals with Elevated Oxidative Stress Biomarkers. J Nutr. 2016 Mar 2. pii: jn222562. [Epub ahead of print]


Mocking RJ, Harmsen I, Assies J, Koeter MW, Ruhé HG, Schene AH. Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder. Transl Psychiatry. 2016 Mar 15;6:e756. doi: 10.1038/tp.2016.29. FULL TEXT


Carney RM, Steinmeyer BC, Freedland KE et al. Baseline blood levels of omega-3 and depression remission: a secondary analysis of data from a placebo-controlled trial of omega-3 supplements. J Clin Psychiatry. 2016 Feb;77(2):e138-43. doi: 10.4088/JCP.14m09660.


Chhetry BT, Hezghia A, Miller JM et al. Omega-3 polyunsaturated fatty acid supplementation and white matter changes in major depression. J Psychiatr Res. 2016 Jan 11;75:65-74. doi: 10.1016/j.jpsychires.2015.12.007. [Epub ahead of print]


Pusceddu MM, El Aidy S, Crispie F, O'Sullivan O, Cotter P, Stanton C, Kelly P, Cryan JF, Dinan TG. N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota. PLoS One. 2015 Oct 1;10(10):e0139721. FULL TEXT


Ginty AT, Conklin SM. Short-term supplementation of acute long-chain omega-3 polyunsaturated fatty acids may alter depression status and decrease symptomology among young adults with depression: A preliminary randomized and placebo controlled trial. Psychiatry Res. 2015 Sep 30;229(1-2):485-9.


Ginty AT, Conklin SM. Short-term supplementation of acute long-chain omega-3 polyunsaturated fatty acids may alterdepression status and decrease symptomology among young adults with depression: Apreliminary randomized and placebo controlled trial. Psychiatry Res. 2015 Jun 27. pii: S0165-1781(15)00384-4. doi: 10.1016/j.psychres.2015.05.072. [Epub ahead of print]


Mocking RJ, Verburg HF, Westerink AM, Assies J, Vaz FM, Koeter MW, Ruhé HG, Schene AH. “Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response.” Psychoneuroendocrinology. 2015 May 11;59:1-13. doi: 10.1016/j.psyneuen.2015.04.027.


Haghighi F, Galfalvy H, Chen S, Huang YY, Cooper TB, Burke AK, Oquendo MA, Mann JJ, Sublette ME. DNA methylation perturbations in genes involved in polyunsaturated Fatty Acid biosynthesis associated with depression and suicide risk. Front Neurol. 2015 Apr 28;6:92. doi: 10.3389/fneur.2015.00092. FULL TEXT


Deacon G, Kettle C, Hayes D, Dennis C, Tucci J. Omega 3 Polyunsaturated Fatty Acids and the Treatment of Depression. Crit Rev Food Sci Nutr. 2015 Apr 1:0.


Rapaport MH, Nierenberg AA, Schettler PJ, Kinkead B, Cardoos A, Walker R, Mischoulon D. Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study. Mol Psychiatry. 2015 Mar 24. doi: 10.1038/mp.2015.22.


Chang JP, Chang SS, Yang HT, Palani M, Chen CP, Su KP. “Polyunsaturated fatty acids (PUFAs) levels in patients with cardiovascular diseases (CVDs) with and without depression.” Brain Behav Immun. 2015 Feb;44:28-31. doi: 10.1016/j.bbi.2014.11.005.


Larrieu T, Hilal LM, Fourrier C, De Smedt-Peyrusse V, Sans N, Capuron L, Layé S. Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion. Transl Psychiatry. 2014 Sep 9;4:e437. FULL TEXT


McNamara RK, Strimpfel J, Jandacek R, Rider T, Tso P, Welge JA, Strawn JR, Delbello MP. Detection and Treatment of Long-Chain Omega-3 Fatty Acid Deficiency in Adolescents with SSRI-Resistant Major Depressive Disorder. PharmaNutrition. 2014 Apr 1;2(2):38-46. FULL TEXT


Beydoun MA, Fanelli Kuczmarski MT, Beydoun HA et al. Omega-3 fatty acid intakes are inversely related to elevated depressive symptoms among United States women. J Nutr. 2013 Sep 4. FULL TEXT


Lang UE, Borgwardt S. Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem. 2013;31(6):761-77.


Lespérance F, Frasure-Smith N, St-André E et al. The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. J Clin Psychiatry. 2011 Aug;72(8):1054-62. doi: 10.4088/JCP.10m05966blu. Epub 2010 Jun 15.


Rondanelli M, Giacosa A, Opizzi A et al. Effect of omega-3 fatty acids supplementation on depressive symptoms and on health-related quality of life in the treatment of elderly women with depression: a double-blind, placebo-controlled, randomized clinical trial. J Am Coll Nutr. 2010 Feb;29(1):55-64.


Lin, PY, Huangb, SY, Su, KP. A Meta¬Analytic Review of Polyunsaturated Fatty Acid Compositions in Patients with Depression Biological Psychiatry 2010;68(2):140¬147.


Mischoulon D, Papakostas GI, Dording CM, Farabaugh AH, Sonawalla SB, Agoston AM, Smith J, Beaumont EC, Dahan LE, Alpert JE, Nierenberg AA, Fava M. A double-blind, randomized controlled trial of ethyl-eicosapentaenoate for major depressive disorder. J Clin Psychiatry. 2009 Dec;70(12):1636-44. Epub 2009 Aug 25. FULL TEXT


Lin PY, Su, KP. A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J Clin Psychiatry. 2007;68:1056-61.


Irmish G, Schläfke D, Gierow W, Herpertz S, Richter J. Fatty acids and sleep in depressed inpatients. Prostaglandins Leuk Essent Fatty Acids. 2007;76:1-7.


McNamara RK, Hahn CG, Jandacek R, Rider T, Tso P, Stanford KE, Richtand NM. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the post-mortem orbitofrontal cortex of patients with major depressive disorder. Biol Psychiatry 2007; 62: 17-24.


Hibbein JR, Ferguson TA, Blasbalg TL. Omega-3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for intervention. Int Rev Psychiatry. 2006;18:107-18.


Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry. 2002;159:477-9.

Posttraumatic stress disorder

Cuéllar-Barboza AB, Sánchez-Ruiz JA, Corral PM. Use of Omega-3 Polyunsaturated Fatty Acids as Augmentation Therapy in Treatment-Resistant Schizophrenia. Prim Care Companion CNS Disord. 2017 May 4;19(3).


Smesny S, Milleit B, Schaefer MR, Hesse J, Schlögelhofer M, Langbein K, Hipler UC, Berger M, Cotter DR, Sauer H, McGorry PD, Amminger GP. Effects of omega-3 PUFA on immune markers in adolescent individuals at ultra-high risk for psychosis - Results of the randomized controlled Vienna omega-3 study. Schizophr Res. 2017 Jan 23.


Koola MM, Raines JK, Hamilton RG et al. Can anti-inflammatory medications improve symptoms and reduce mortality in schizophrenia? Curr Psychiatr. 2016 May;15(5):52-57. Epub 2016 Apr 25. FULL TEXT


Kim SW, Jhon M, Kim JM et al. Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study. PLoS One. 2016 Mar 10;11(3):e0151417. doi: 10.1371/journal.pone.0151417. eCollection 2016. FULL TEXT


Gavzan H, Sayyah M, Sardari S, Babapour V. Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. Naunyn Schmiedebergs Arch Pharmacol. 2015 Oct;388(10):1029-38.


Vesco AT, Lehmann J, Gracious BL, Arnold LE, Young AS, Fristad MA. Omega-3 Supplementation for Psychotic Mania and Comorbid Anxiety in Children. J Child Adolesc Psychopharmacol. 2015 Sep;25(7):526-34.


Kokacya MH, Inanir S, Copoglu US, Dokuyucu R, Erbas O. The Antipsychotic Effects of Omega-3 Fatty Acids in Rats. Am J Med Sci. 2015 Sep;350(3):212-7.


Amminger GP, Schäfer MR, Schlögelhofer M, Klier CM, McGorry PD. Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study. Nat Commun. 2015 Aug 11;6:7934.


Ramsden CE, Faurot KR, Zamora D, Palsson OS, MacIntosh BA, Gaylord S, Taha AY, Rapoport SI, Hibbeln JR, Davis JM, Mann JD. Targeted alterations in dietary n-3 and n-6 fatty acids improve life functioning and reduce psychological distress among patients with chronic headache: a secondary analysis of a randomized trial. Pain. 2015 Apr;156(4):587-96. doi: 10.1097/01.j.pain.0000460348.84965.47


Amminger GP, Schäfer MR, Papageorgiou K et al. Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry. 2010 Feb;67(2):146-54.

Psychotic disorders

Substance abuse