Studies

Pediatrics

Allergies

Asthma

Bisgaard H, Stokholm J, Chawes BL, Vissing NH, Bjarnadóttir E, Schoos AM, Wolsk HM, Pedersen TM1, Vinding RK, Thorsteinsdóttir S, Følsgaard NV, Fink NR, Thorsen J, Pedersen AG, Waage J, Rasmussen MA, Stark KD, Olsen SF, Bønnelykke K. Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring. N Engl J Med. 2016 Dec 29;375(26):2530-9.


Farjadian S, Moghtaderi M, Kalani M, Gholami T, Hosseini Teshnizi S. Effects of omega-3 fatty acids on serum levels of T-helper cytokines in children with asthma. Cytokine. 2016 Sep;85:61-6. doi: 10.1016/j.cyto.2016.06.002. Epub 2016 Jun 9.


Farjadian S, Moghtaderi M, Kalani M et al. Effects of omega-3 fatty acids on serum levels of T-helper cytokines in children with asthma. Cytokine. 2016 Jun 8;85:61-66. doi: 10.1016/j.cyto.2016.06.002. [Epub ahead of print]


Kumar A, Mastana SS, Lindley MR. n-3 Fatty acids and asthma. Nutr Res Rev. 2016 Jan 26:1-16. [Epub ahead of print]


Malan L, Baumgartner J, Calder PC, Zimmermann MB, Smuts CM. “n-3 Long-chain PUFAs reduce respiratory morbidity caused by iron supplementation in iron-deficient South African schoolchildren: a randomized, double-blind, placebo-controlled intervention.” Am J Clin Nutr. 2015 Mar;101(3):668-79. doi: 10.3945/ajcn.113.081208.


Brannan JD, Bood J, Alkhabaz A, Balgoma D, Otis J, Delin I, Dahlén B, Wheelock CE, Nair P, Dahlén SE, O'Byrne PM. The effect of omega-3 fatty acids on bronchial hyperresponsiveness, sputum eosinophilia, and mast cell mediators in asthma. Chest. 2015 Feb;147(2):397-405.


Hageman JHJ,Hooyenga P, Diersen¬Schade DA et al. The Impact of Dietary Long¬Chain Polyunsaturated Fatty Acids on Respiratory Illness in Infants and Children. Curr Allergy Asthma Rep 2012;12(6):564¬573. FULL TEXT

Neurological development of the fetus and children

Vollet K, Ghassabian A, Sundaram R et al. Prenatal fish oil supplementation and early childhood development in the Upstate KIDS Study. J Dev Orig Health Dis. 2017 Apr 24:1-9.


Collado MC, Santaella M, Mira-Pascual L, Martínez-Arias E, Khodayar-Pardo P, Ros G, Martínez-Costa C. Longitudinal Study of Cytokine Expression, Lipid Profile and Neuronal Growth Factors in Human Breast Milk from Term and Preterm Deliveries. Nutrients. 2015 Oct 19;7(10):8577-91.


Almeida DM, Jandacek RJ, Weber WA, McNamara RK. Docosahexaenoic acid biostatus is associated with event-related functional connectivity in cortical attention networks of typically developing children. Nutr Neurosci. 2015 Oct 13.


Guemez-Gamboa A, Nguyen LN, Yang H, Zaki MS, Kara M, Ben-Omran T, Akizu N, Rosti RO, Rosti B, Scott E, Schroth J, Copeland B, Vaux KK, Cazenave-Gassiot A, Quek DQ, Wong BH, Tan BC, Wenk MR, Gunel M, Gabriel S, Chi NC, Silver DL, Gleeson JG. Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nat Genet. 2015 May 25. doi: 10.1038/ng.3311.


Sherry CL, Oliver JS, Marriage BJ. Docosahexaenoic acid supplementation in lactating women increases breast milk and plasma docosahexaenoic acid concentrations and alters infant omega 6:3 fatty acid ratio. Prostaglandins Leukot Essent Fatty Acids. 2015 Apr;95:63-9. doi: 10.1016/j.plefa.2015.01.005. FULL TEXT


Strickland AD. Prevention of cerebral palsy, autism spectrum disorder, and attention deficit - Hyperactivity disorder. Med Hypotheses. 2014 May;82(5):522-8.


Williams JJ, Mayurasakorn K, Vannucci SJ et al. N-3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice. PLoS One. 2013;8(2):e56233. doi: 10.1371/journal.pone.0056233. Epub 2013 Feb 20. FULL TEXT


Morse NL. Benefits of docosahexaenoic acid, folic acid, vitamin D and iodine on foetal and infant brain development and function following maternal supplementation during pregnancy and lactation. Nutrients. 2012;4(7):799-840. FULL TEXT


Zhang W, Hu X, Yang W, Gao Y, Chen J. Omega-3 polyunsaturated fatty acid supplementation confers long-term neuroprotection against neonatal hypoxic-ischemic brain injury through anti-inflammatory actions. Stroke. 2010 Oct;41(10):2341-7. FULL TEXT


Gil-Campos M, Dalmau Serra J; Comité de Nutrición de la Asociación Española de Pediatría. [Importance of docosahexaenoic acid (DHA): Functions and recommendations for its ingestion in infants]. An Pediatr (Barc). 2010 Sep;73(3):142.e1-8. Epub 2010 Jun 8. FULL TEXT


Carlson SE. Docosahexaenoic acid supplementation in pregnancy and lactation. Am J Clin Nutr. 2009 Feb;89(2):678S-84S. Epub 2008 Dec 30. FULL TEXT


Carlson SE. Docosahexaenoic acid supplementation in pregnancy and lactation. Am J Clin Nutr. 2009 Feb;89(2):678S-84S. Epub 2008 Dec 30. FULL TEXT


Levant B, Radel JD, Carlson SE. Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation. Behav Brain Res 2004;152:49-57.


Valenzuela A, Nieto S. Ácido docosahexaenoico (DHA) en el desarrollo fetal y en la nutrición materno-infantil. Rev Med Chile. 2001;129:1203-11. FULL TEXT


Valenzuela A, Nieto S. Ácido docosahexaenoico (DHA) en el desarrollo fetal y en la nutrición materno-infantil. Rev Med Chile. 2001;129:1203-11. FULL TEXT

Premature infants

Vayalthrikkovil S, Bashir RA, Rabi Y, Amin H, Spence JM, Robertson HL, Lodha A. Parenteral Fish-Oil Lipid Emulsions in the Prevention of Severe Retinopathy of Prematurity: A Systematic Review and Meta-Analysis. Am J Perinatol. 2016 Dec 19.


Meher A, Randhir K, Mehendale S et al. Maternal Fatty Acids and Their Association with Birth Outcome: A Prospective Study. PLoS One. 2016 Jan 27;11(1):e0147359. doi: 10.1371/journal.pone.0147359. eCollection 2016. FULL TEXT


Tam EW, Chau V, Barkovich AJ et al. Early postnatal docosahexaenoic acid levels and improved preterm brain development. Pediatr Res. 2016 Jan 13. doi: 10.1038/pr.2016.11. [Epub ahead of print]


Sharma D , Nkembi AS, Aubry E, Houeijeh A, Butruille L, Houfflin-Debarge V, Besson R, Deruelle P, Storme L. Maternal PUFA ω-3 Supplementation Prevents Neonatal Lung Injuries Induced by Hyperoxia in Newborn Rats. Int J Mol Sci. 2015 Sep 14;16(9):22081-93. FULL TEXT


Yang Q, Ayers K, Chen Y, O'Shea TM. Early Enteral Fat Supplementation Improves Protein Absorption in Premature Infants with an Enterostomy. Neonatology. 2014 Mar 6;106(1):10-16.


Hellström A, Smith LE, Dammann O. Retinopathy of prematurity. Lancet. 2013 Oct 26;382(9902):1445-57. FULL TEXT


Skilton MR, Raitakari OT, Celermajer DS. High intake of dietary long-chain ?-3 fatty acids is associated with lower blood pressure in children born with low birth weight: NHANES 2003-2008. Hypertension. 2013 May;61(5):972-6. FULL TEXT


Crawford M. Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. Am J Clin Nutr 2000; 71: 275-84. FULL TEXT

Sleep

Visual and cognitive development in children

Sheppard KW, Cheatham CL. Executive functions and the ω-6-to-ω-3 fatty acid ratio: a cross-sectional study. Am J Clin Nutr. 2017 Jan;105(1):32-41.


Johnson M, Fransson G, Östlund S, Areskoug B, Gillberg C. Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-controlled trial in 9-year-old mainstream schoolchildren in Sweden. J Child Psychol Psychiatry. 2016 Aug 22. doi: 10.1111/jcpp.12614. [Epub ahead of print]


Fu Z, Lofqvist CA, Shao Z, Sun Y, Joyal JS, Hurst CG, Cui RZ, Evans LP, Tian K, SanGiovanni JP, Chen J, Ley D, Hansen Pupp I, Hellstrom A, Smith LE. Dietary ω-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr;101(4):879-88. doi: 10.3945/ajcn.114.099291.


Colombo J, Carlson SE, Cheatham CL, Shaddy DJ, Kerling EH, Thodosoff JM, Gustafson KM, Brez C. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013 Aug;98(2):403-12. FULL TEXT


Kuratko CN, Barrett EC, Nelson EB et al. The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. Nutrients. 2013 Jul 19;5(7):2777-2810. FULL TEXT


Lassek WD, Gaulin SJ. Maternal milk DHA content predicts cognitive performance in 28 nations. Matern Child Nutr 2013; Jun 25 doi: 10.1111/mcn.12060


Richardson AJ, Burton JR, Sewell RP et al. Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB Study). PLoS One 2012;7(9):e43909. FULL TEXT


Jacques C, Levy E, Muckle G et al. Long-term effects of prenatal omega-3 fatty acid intake on visual function in school-age children. J Pediatr 2011;158(1):83-90. FULL TEXT


Birch EE, Carlson SE, Hoffman DR et al. The DIAMOND (DHA Intake And Measurement Of Neural Development) Study: a double-masked, randomized controlled clinical trial of the maturation of infant visual acuity as a function of the dietary level of docosahexaenoic acid. Am J Clin Nutr. 2010 Apr;91(4):848-59. FULL TEXT


Heird WC, Lapillonne A. The role of essential fatty acids in development. Annu Rev Nutr. 2005;25:54971.


Uauy R, Hoffman D, Peirano P, Birch D, Birch E. Essential fatty acids in visual and brain development. Lipids. 2001;36:885-95.


Uauy R, Mena P, Valenzuela A. Essential fatty acids as determinants of lipid requirements in infants, children and adults. Eur J Clin Nutr 1999; 53: 66-77


Cunnane S. Fatty acid profiles of maternal adipose tissue in relation to infant development. Brit J Nutr 1999; 82: 253-4.


Birch E, Hoffman D, Uauy R. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res 1998; 44: 1-9.


Agostoni C, Trojan S, Bellú R, Riva E, Brunezze M, Giovannini M. Developmental quotient at 24 months and fatty acid composition of diet in early infancy: a follow-up study. Arch Dis Child. 1997;76:421-4. FULL TEXT


Agostoni C, Trojan S, Bellú R, Riva E, Brunezze M, Giovannini M. Developmental quotient at 24 months and fatty acid composition of diet in early infancy: a follow-up study. Arch Dis Child. 1997;76:421-4. FULL TEXT


Sastry P. Lipids in the nervous system: Compo sition and metabolism. Prog Lipid Res. 1985;24:69-176.