Studies

Omega-3 basic concepts

Calder PC. Docosahexaenoic Acid. Ann Nutr Metab. 2016;69 Suppl 1:7-21. Epub 2016 Nov 15. FULL TEXT


Markworth JF, Kaur G, Miller EG, Larsen AE, Sinclair AJ, Maddipati KR, Cameron-Smith D. Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid. FASEB J. 2016 Jul 26. pii: fj.201600360R. [Epub ahead of print]


Kurtys E, Eisel UL, Verkuyl JM, Broersen LM, Dierckx RA, de Vries EF. The combination of vitamins and omega-3 fatty acids has an enhanced anti-inflammatory effect on microglia. Neurochem Int. 2016 Jul 25;99:206-214. doi: 10.1016/j.neuint.2016.07.008. [Epub ahead of print]


Schunck WH. EPA and/or DHA? A test question on the principles and opportunities in utilizing the therapeutic potential of omega-3 fatty acids. J Lipid Res. 2016 Jul 19. pii: jlr.C071084. [Epub ahead of print]


Hashimoto M, Hossain S, Al Mamun A, Matsuzaki K, Arai H. Docosahexaenoic acid: one molecule diverse functions. Crit Rev Biotechnol. 2016 Jul 17:1-19. [Epub ahead of print] FULL TEXT


Cutuli D. Functional and structural benefits induced by omega-3 polyunsaturated fatty acids during aging. Curr Neuropharmacol. 2016 Jun 13. [Epub ahead of print]


Li L, Wang B, Yu P, Wen X, Gong D, Zeng Z. Medium and Long Chain Fatty Acids Differentially Modulate Apoptosis and Release of Inflammatory Cytokines in Human Liver Cells. J Food Sci. 2016 Jun;81(6):H1546-52. doi: 10.1111/1750-3841.13321. Epub 2016 May 3.


Gu Y, Vorburger RS, Gazes Y et al. White matter integrity as a mediator in the relationship between dietary nutrients and cognition in the elderly. Ann Neurol. 2016 Apr 30. doi: 10.1002/ana.24674. [Epub ahead of print]


D'Ascoli TA, Mursu J, Voutilainen S et al. Association between serum long-chain omega-3 polyunsaturated fatty acids and cognitive performance in elderly men and women: The Kuopio Ischaemic Heart Disease Risk Factor Study. Eur J Clin Nutr. 2016 Apr 13. doi: 10.1038/ejcn.2016.59. [Epub ahead of print]


Da Silva MS, Rudkowska I. Novel functional foods for optimal oxidative status in healthy ageing. Maturitas. 2016 Apr 4. pii: S0378-5122(16)30073-1. doi: 10.1016/j.maturitas.2016.04.001. [Epub ahead of print]


Noriega BS, Sanchez-Gonzalez MA, Salyakina D et al. Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota. Case Rep Med. 2016;2016:3089303. doi: 10.1155/2016/3089303. Epub 2016 Mar 14. FULL TEXT


Weiser MJ, Butt CM, Mohajeri MH. Docosahexaenoic Acid and Cognition throughout the Lifespan. Nutrients. 2016 Feb 17;8(2). pii: E99. doi: 10.3390/nu8020099. FULL TEXT


Le Donne M, Alibrandi A, Vita R et al. Does eating oily fish improve gestational and neonatal outcomes? Findings from a Sicilian study. Women Birth. 2016 Jan 30. pii: S1871-5192(16)00002-0. doi: 10.1016/j.wombi.2015.12.005. [Epub ahead of print]


Gil Hernández A. Metabolismo y actividad biológica de los ácidos grasos omega-3. Nutrición y dietética 2004; 1(9): 69.


Tu WC, Cook-Johnson RJ, James MJ, Mühlhäusler BS, Gibson RA. Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression. Prostaglandins Leukot Essent Fatty Acids. 2010 Aug;83(2):61-8. Epub 2010 Jun 22.


Wiktorowska-Owczarek A, Berezińska M, Nowak JZ. PUFAs: Structures, Metabolism and Functions. Adv Clin Exp Med. 2015;24(6):931–41. FULL TEXT


Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL, Silver DL. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature. 2014 May 14. doi: 10.1038/nature13241. [Epub ahead of print]


Bürgin-Maunder CS, Brooks PR, Russell FD. Omega-3 Fatty Acids Modulate Weibel-Palade Body Degranulation and Actin Cytoskeleton Rearrangement in PMA-Stimulated Human Umbilical Vein Endothelial Cells. Mar Drugs. 2013 Nov 8;11(11):4435-50. FULL TEXT


Dalli J, Colas RA, Serhan CN. Novel n-3 immunoresolvents: structures and actions. Sci Rep. 2013;3:1940. FULL TEXT


Russell FD, Bürgin-Maunder CS. Distinguishing health benefits of eicosapentaenoic and docosahexaenoic acids. Mar Drugs. 2012 Nov 13;10(11):2535-59. FULL TEXT


Calder PC. Mechanisms of action of (n-3) fatty acids. J Nutr. 2012 Mar;142(3):592S-599S. FULL TEXT


Weylandt KH, Chiu CY, Gomolka B et al. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. Prostaglandins Other Lipid Mediat. 2012 Mar;97(3-4):73-82.


Issazadeh-Navikas S, Teimer R, Bockermann R. Influence of dietary components on regulatory T cells. Mol Med. 2012 Feb 10;18:95-110. FULL TEXT


Swanson D, Block R, Mousa SA. Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv Nutr. 2012 Jan;3(1):1-7. FULL TEXT


Kremmyda LS, Tvrzicka E, Stankova B, Zak A. Fatty acids as biocompounds: their role in human metabolism, health and disease: a review. part 2: fatty acid physiological roles and applications in human health and disease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011 Sep;155(3):195-218. FULL TEXT


Bazan NG, Molina MF, Gordon WC. Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. Annu Rev Nutr. 2011 Aug 21;31:321-51. FULL TEXT


Fredman G, Serhan CN. Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution. Biochem J. 2011 Jul 15;437(2):185-97. FULL TEXT


Tvrzicka E, Kremmyda LS, Stankova B, Zak A. Fatty acids as biocompounds: their role in human metabolism, health and disease--a review. Part 1: classification, dietary sources and biological functions. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011 Jun;155(2):117-30. FULL TEXT


Catalá A. A synopsis of the process of lipid peroxidation since the discovery of the essential fatty acids. Biochem Biophys Res Commun. 2010 Aug 27;399(3):318-23. Epub 2010 Jul 30.


Auinger A, Helwig U, Rubin D, Herrmann J, Jahreis G, Pfeuffer M, de Vrese M, Foelsch UR, Schreiber S, Doering F, Schrezenmeir J. Human intestinal fatty acid binding protein 2 expression is associated with fat intake and polymorphisms. J Nutr. 2010 Aug;140(8):1411-7. Epub 2010 Jun 9. FULL TEXT


Akhtar Khan N. Polyunsaturated fatty acids in the modulation of T-cell signalling. Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):179-87.


Catalá A. The function of very long chain polyunsaturated fatty acids in the pineal gland. Biochim Biophys Acta. 2010 Feb;1801(2):95-9. Epub 2009 Oct 30.


Muskiet FAJ. Fat Detection: Taste, Texture, and Post Ingestive Effects. Chapter 2: Pathophysiology and Evolutionary Aspects of Dietary Fats and Long-Chain Polyunsaturated Fatty Acids across the Life Cycle Montmayeur JP, le Coutre J, editors. Boca Raton (FL): CRC Press; 2010. FULL TEXT


Kopecky J, Rossmeisl M, Flachs P, Kuda O, Brauner P, Jilkova Z, Stankova B, Tvrzicka E, Bryhn M. n-3 PUFA: bioavailability and modulation of adipose tissue function. Proc Nutr Soc. 2009 Nov;68(4):361-9. Epub 2009 Aug 24.


Flachs P, Rossmeisl M, Bryhn M, Kopecky J. Cellular and molecular effects of n-3 polyunsaturated fatty acids on adipose tissue biology and metabolism. Clin Sci (Lond). 2009 Jan;116(1):1-16.


Jump DB, Botolin D, Wang Y, Xu J, Demeure O, Christian B. Docosahexaenoic acid (DHA) and hepatic gene transcription. Chem Phys Lipids. 2008 May;153(1):3-13. Epub 2008 Feb 23. FULL TEXT


Jump DB. N-3 polyunsaturated fatty acid regulation of hepatic gene transcription. Curr Opin Lipidol. 2008 Jun;19(3):242-7. FULL TEXT


Hulbert AJ. Membrane fatty acids as pacemakers of animal metabolism. Lipids. 2007 Sep;42(9):811-9. Epub 2007 Apr 27.


Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1467S-1476S. FULL TEXT


Caballero, R, Gómez R, Núñez L. Farmacología de los ácidos grasos omega-3. Rev Esp Cardiol. 2006;6(Suppl.):3D-19D. FULL TEXT


Seo T, Blazer WS, Deckelbaum RJ. Omega-3 fatty acids: molecular approaches to optimal biological outcomes. Curr Opin Lipidol 2005; 16: 11-18.


Clarke SD. The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors. Curr Opin Lipidol. 2004 Feb;15(1):13-8.


Xu J, Nakamura MT, Cho HP, Clarke SD. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J Biol Chem. 1999 Aug 13;274(33):23577-83. FULL TEXT

Bioequivalence

Cognitive development