Omega-3 basic concepts

Croft D, Block R, Cameron SJ, Evans K, Lowenstein CJ, Ling F, et al. Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen? Air Qual Atmos Health. 2018;11(7):791-9.

Xu J, Gaddis NC, Bartz TM, Hou R, Manichaikul AW, Pankratz N, et al. Omega-3 fatty acids and genome-wide interaction analyses reveal DPP10-pulmonary function association. Am J Respir Crit Care Med. 2018 Sep 10. doi: 10.1164/rccm.201802-0304OC. [Epub ahead of print]

Arigliani M, Spinelli AM, Liguoro I, Cogo P. Nutrition and lung growth. Nutrients. 2018;10(7). doi: 10.3390/nu10070919.

Calder PC. Docosahexaenoic Acid. Ann Nutr Metab. 2016;69 Suppl 1:7-21. Epub 2016 Nov 15. FULL TEXT

Markworth JF, Kaur G, Miller EG, Larsen AE, Sinclair AJ, Maddipati KR, Cameron-Smith D. Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid. FASEB J. 2016 Jul 26. pii: fj.201600360R. [Epub ahead of print]

Kurtys E, Eisel UL, Verkuyl JM, Broersen LM, Dierckx RA, de Vries EF. The combination of vitamins and omega-3 fatty acids has an enhanced anti-inflammatory effect on microglia. Neurochem Int. 2016 Jul 25;99:206-214. doi: 10.1016/j.neuint.2016.07.008. [Epub ahead of print]

Schunck WH. EPA and/or DHA? A test question on the principles and opportunities in utilizing the therapeutic potential of omega-3 fatty acids. J Lipid Res. 2016 Jul 19. pii: jlr.C071084. [Epub ahead of print]

Hashimoto M, Hossain S, Al Mamun A, Matsuzaki K, Arai H. Docosahexaenoic acid: one molecule diverse functions. Crit Rev Biotechnol. 2016 Jul 17:1-19. [Epub ahead of print] FULL TEXT

Li L, Wang B, Yu P, Wen X, Gong D, Zeng Z. Medium and Long Chain Fatty Acids Differentially Modulate Apoptosis and Release of Inflammatory Cytokines in Human Liver Cells. J Food Sci. 2016 Jun;81(6):H1546-52. doi: 10.1111/1750-3841.13321. Epub 2016 May 3.

Cutuli D. Functional and structural benefits induced by omega-3 polyunsaturated fatty acids during aging. Curr Neuropharmacol. 2016 Jun 13. [Epub ahead of print]

Gu Y, Vorburger RS, Gazes Y et al. White matter integrity as a mediator in the relationship between dietary nutrients and cognition in the elderly. Ann Neurol. 2016 Apr 30. doi: 10.1002/ana.24674. [Epub ahead of print]

D'Ascoli TA, Mursu J, Voutilainen S et al. Association between serum long-chain omega-3 polyunsaturated fatty acids and cognitive performance in elderly men and women: The Kuopio Ischaemic Heart Disease Risk Factor Study. Eur J Clin Nutr. 2016 Apr 13. doi: 10.1038/ejcn.2016.59. [Epub ahead of print]

Da Silva MS, Rudkowska I. Novel functional foods for optimal oxidative status in healthy ageing. Maturitas. 2016 Apr 4. pii: S0378-5122(16)30073-1. doi: 10.1016/j.maturitas.2016.04.001. [Epub ahead of print]

Noriega BS, Sanchez-Gonzalez MA, Salyakina D et al. Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota. Case Rep Med. 2016;2016:3089303. doi: 10.1155/2016/3089303. Epub 2016 Mar 14. FULL TEXT

Weiser MJ, Butt CM, Mohajeri MH. Docosahexaenoic Acid and Cognition throughout the Lifespan. Nutrients. 2016 Feb 17;8(2). pii: E99. doi: 10.3390/nu8020099. FULL TEXT

Le Donne M, Alibrandi A, Vita R et al. Does eating oily fish improve gestational and neonatal outcomes? Findings from a Sicilian study. Women Birth. 2016 Jan 30. pii: S1871-5192(16)00002-0. doi: 10.1016/j.wombi.2015.12.005. [Epub ahead of print]

Gil Hernández A. Metabolismo y actividad biológica de los ácidos grasos omega-3. Nutrición y dietética 2004; 1(9): 69.

Tu WC, Cook-Johnson RJ, James MJ, Mühlhäusler BS, Gibson RA. Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression. Prostaglandins Leukot Essent Fatty Acids. 2010 Aug;83(2):61-8. Epub 2010 Jun 22.

Wiktorowska-Owczarek A, Berezińska M, Nowak JZ. PUFAs: Structures, Metabolism and Functions. Adv Clin Exp Med. 2015;24(6):931–41. FULL TEXT

Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL, Silver DL. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature. 2014 May 14. doi: 10.1038/nature13241. [Epub ahead of print]

Bürgin-Maunder CS, Brooks PR, Russell FD. Omega-3 Fatty Acids Modulate Weibel-Palade Body Degranulation and Actin Cytoskeleton Rearrangement in PMA-Stimulated Human Umbilical Vein Endothelial Cells. Mar Drugs. 2013 Nov 8;11(11):4435-50. FULL TEXT

Dalli J, Colas RA, Serhan CN. Novel n-3 immunoresolvents: structures and actions. Sci Rep. 2013;3:1940. FULL TEXT

Russell FD, Bürgin-Maunder CS. Distinguishing health benefits of eicosapentaenoic and docosahexaenoic acids. Mar Drugs. 2012 Nov 13;10(11):2535-59. FULL TEXT

Weylandt KH, Chiu CY, Gomolka B et al. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. Prostaglandins Other Lipid Mediat. 2012 Mar;97(3-4):73-82.

Calder PC. Mechanisms of action of (n-3) fatty acids. J Nutr. 2012 Mar;142(3):592S-599S. FULL TEXT

Issazadeh-Navikas S, Teimer R, Bockermann R. Influence of dietary components on regulatory T cells. Mol Med. 2012 Feb 10;18:95-110. FULL TEXT

Swanson D, Block R, Mousa SA. Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv Nutr. 2012 Jan;3(1):1-7. FULL TEXT

Kremmyda LS, Tvrzicka E, Stankova B, Zak A. Fatty acids as biocompounds: their role in human metabolism, health and disease: a review. part 2: fatty acid physiological roles and applications in human health and disease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011 Sep;155(3):195-218. FULL TEXT

Bazan NG, Molina MF, Gordon WC. Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. Annu Rev Nutr. 2011 Aug 21;31:321-51. FULL TEXT

Fredman G, Serhan CN. Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution. Biochem J. 2011 Jul 15;437(2):185-97. FULL TEXT

Tvrzicka E, Kremmyda LS, Stankova B, Zak A. Fatty acids as biocompounds: their role in human metabolism, health and disease--a review. Part 1: classification, dietary sources and biological functions. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011 Jun;155(2):117-30. FULL TEXT

Catalá A. A synopsis of the process of lipid peroxidation since the discovery of the essential fatty acids. Biochem Biophys Res Commun. 2010 Aug 27;399(3):318-23. Epub 2010 Jul 30.

Auinger A, Helwig U, Rubin D, Herrmann J, Jahreis G, Pfeuffer M, de Vrese M, Foelsch UR, Schreiber S, Doering F, Schrezenmeir J. Human intestinal fatty acid binding protein 2 expression is associated with fat intake and polymorphisms. J Nutr. 2010 Aug;140(8):1411-7. Epub 2010 Jun 9. FULL TEXT

Akhtar Khan N. Polyunsaturated fatty acids in the modulation of T-cell signalling. Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):179-87.

Catalá A. The function of very long chain polyunsaturated fatty acids in the pineal gland. Biochim Biophys Acta. 2010 Feb;1801(2):95-9. Epub 2009 Oct 30.

Muskiet FAJ. Fat Detection: Taste, Texture, and Post Ingestive Effects. Chapter 2: Pathophysiology and Evolutionary Aspects of Dietary Fats and Long-Chain Polyunsaturated Fatty Acids across the Life Cycle Montmayeur JP, le Coutre J, editors. Boca Raton (FL): CRC Press; 2010. FULL TEXT

Kopecky J, Rossmeisl M, Flachs P, Kuda O, Brauner P, Jilkova Z, Stankova B, Tvrzicka E, Bryhn M. n-3 PUFA: bioavailability and modulation of adipose tissue function. Proc Nutr Soc. 2009 Nov;68(4):361-9. Epub 2009 Aug 24.

Flachs P, Rossmeisl M, Bryhn M, Kopecky J. Cellular and molecular effects of n-3 polyunsaturated fatty acids on adipose tissue biology and metabolism. Clin Sci (Lond). 2009 Jan;116(1):1-16.

Jump DB, Botolin D, Wang Y, Xu J, Demeure O, Christian B. Docosahexaenoic acid (DHA) and hepatic gene transcription. Chem Phys Lipids. 2008 May;153(1):3-13. Epub 2008 Feb 23. FULL TEXT

Jump DB. N-3 polyunsaturated fatty acid regulation of hepatic gene transcription. Curr Opin Lipidol. 2008 Jun;19(3):242-7. FULL TEXT

Hulbert AJ. Membrane fatty acids as pacemakers of animal metabolism. Lipids. 2007 Sep;42(9):811-9. Epub 2007 Apr 27.

Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1467S-1476S. FULL TEXT

Caballero, R, Gómez R, Núñez L. Farmacología de los ácidos grasos omega-3. Rev Esp Cardiol. 2006;6(Suppl.):3D-19D. FULL TEXT

Seo T, Blazer WS, Deckelbaum RJ. Omega-3 fatty acids: molecular approaches to optimal biological outcomes. Curr Opin Lipidol 2005; 16: 11-18.

Clarke SD. The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors. Curr Opin Lipidol. 2004 Feb;15(1):13-8.

Xu J, Nakamura MT, Cho HP, Clarke SD. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J Biol Chem. 1999 Aug 13;274(33):23577-83. FULL TEXT


Cognitive development

The effect of Atlantic salmon consumption on the cognitive performance of preschool children - A randomized controlled trial. Clin Nutr. 2018 Dec 22. pii: S0261-5614(18)32564-0. doi: 10.1016/j.clnu.2018.11.031. [Epub ahead of print]

Bolt LK, Amminger GP, Farhall J, McGorry PD, Nelson B, Markulev C, Yuen HP, Schäfer MR, Mossaheb N, Schlögelhofer M, Smesny S, Hickie IB, Berger GE, Chen EYH, de Haan L, Nieman DH, Nordentoft M, Riecher-Rössler A, Verma S, Thompson A, Yung AR, Allott KA.Neurocognition as a predictor of transition to psychotic disorder and functional outcomes in ultra-high risk participants: Findings from the NEURAPRO randomized clinical trial. Schizophr Res. 2018 Dec 14. pii: S0920-9964(18)30701-1. doi: 10.1016/j.schres.2018.12.013. [Epub ahead of print]

Assmann KE, Adjibade M, Hercberg S, Galan P, Kesse-Guyot E. Unsaturated Fatty Acid Intakes During Midlife Are Positively Associated with Later Cognitive Function in Older Adults with Modulating Effects of Antioxidant Supplementation. J Nutr. 2018 Dec 1;148(12):1938-1945. doi: 10.1093/jn/nxy206.

Zwilling CE, Talukdar T, Zamroziewicz MK, Barbey AK. Nutrient biomarker patterns, cognitive function, and fMRI measures of network efficiency in the aging brain. Neuroimage. 2018 Dec 7;188:239-251. doi: 10.1016/j.neuroimage.2018.12.007. [Epub ahead of print]

Abdullah M, Jowett B, Whittaker PJ, Patterson L. The effectiveness of omega-3 supplementation in reducing ADHD associated symptoms in children as measured by the Conners' rating scales: A systematic review of randomized controlled trials. J Psychiatr Res. 2018 Dec 12;110:64-73. doi: 10.1016/j.jpsychires.2018.12.002. [Epub ahead of print]

Willatts P. Effects of nutrition on the development of higher-order cognition. Nestle Nutr Inst Workshop Ser. 2018;89:175-84.

van der Wurff IS, von Schacky C, Berge K et al. Association between Blood Omega-3 Index and Cognition in Typically Developing Dutch Adolescents. Nutrients. 2016 Jan 2;8(1). pii: E13. doi: 10.3390/nu8010013. FULL TEXT