Studies

Neurology

Hernando S, Requejo C, Herran E, Ruiz-Ortega JA, Morera-Herreras T, Lafuente JV, et al. Beneficial effects of n-3 polyunsaturated fatty acids administration in a partial lesion model of Parkinson's disease: The role of glia and NRf2 regulation. Neurobiol Dis. 2018;121:252-62.

Abdolahi M, Tafakhori A, Togha M et al. The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients. Immunogenetics. 2017 Jun;69(6):371-378.

McNamara RK, Asch RH, Lindquist DM et al. Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: An update on neuroimaging findings. Prostaglandins Leukot Essent Fatty Acids. 2017 May 9.

Dong Y, Xu M, Kalueff AV et al. Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1β administration. Eur J Nutr. 2017 May 18.

Andreone BJ, Wai Chow B, Tata A, Lacoste B, Ben-Zvi A, Bullock K, Deik AA, Ginty DD, Clish CB, Gu C. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron. 2017 May 3;94(3):581-594.e5. doi: 10.1016/j.neuron.2017.03.043. Epub 2017 Apr 13.

Siegert E, Paul F, Rothe M, Weylandt KH. The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice. BMC Neurosci. 2017 Jan 24;18(1):19. FULL TEXT

Liu ZH, Yip PK, Priestley JV, Michael-Titus AT. A Single Dose of Docosahexaenoic Acid Increases the Functional Recovery Promoted by Rehabilitation after Cervical Spinal Cord Injury in the Rat. J Neurotrauma. 2017 Jan 13.

Amyotrophic lateral sclerosis

Autism

Keim SA, Gracious B, Boone KM, Klebanoff MA, Rogers LK, Rausch J, et al. ω-3 and ω-6 Fatty Acid Supplementation May Reduce Autism Symptoms Based on Parent Report in Preterm Toddlers. J Nutr. 2018;148(2):227-35.

Agostoni C, Nobile M, Ciappolino V, Delvecchio G, Tesei A, Turolo S, et al. The Role of Omega-3 Fatty Acids in Developmental Psychopathology: A Systematic Review on Early Psychosis, Autism, and ADHD. Int J Mol Sci. 2017;18(12).

Cheng YS, Tseng PT, Chen YW, et al. Supplementation of omega 3 fatty acids may improve hyperactivity, lethargy, and stereotypy in children with autism spectrum disorders: a meta-analysis of randomized controlled trials. Neuropsychiatr Dis Treat. 2017 Oct 4;13:2531-43.

Children

Parellada M, Llorente C, Calvo R, et al. Randomized trial of omega-3 for autism spectrum disorders: Effect on cell membrane composition and behavior. Eur Neuropsychopharmacol. 2017 Sep 18.

Sheppard KW, Boone KM, Gracious B, Klebanoff MA, Rogers LK, Rausch J, et al. Effect of Omega-3 and -6 Supplementation on Language in Preterm Toddlers Exhibiting Autism Spectrum Disorder Symptoms. J Autism Dev Disord. 2017 Jul 26. [Epub ahead of print]

Brigandi SA, Shao H, Qian SY et al. Autistic children exhibit decreased levels of essential Fatty acids in red blood cells. Int J Mol Sci. 2015 May 4;16(5):10061-76. doi: 10.3390/ijms160510061. FULL TEXT

Brigandi SA, Shao H, Qian SY, Shen Y, Wu BL, Kang JX. Autistic children exhibit decreased levels of essential Fatty acids in red blood cells. Int J Mol Sci. 2015 May 4;16(5):10061-76. doi: 10.3390/ijms160510061. FULL TEXT

Yan CL, Zhang J, Hou Y. Decreased plasma levels of lipoxin A4 in children with autism spectrum disorders. Neuroreport. 2015 Apr 15;26(6):341-5. doi: 10.1097/WNR.

Ooi YP, Weng SJ, Jang LY, Low L, Seah J, Teo S, Ang RP, Lim CG, Liew A, Fung DS, Sung M. Omega-3 fatty acids in the management of autism spectrum disorders: findings from an open-label pilot study in Singapore. Eur J Clin Nutr. 2015 Mar 25. doi: 10.1038/ejcn.2015.28.

Al-Farsi YM, Waly MI, Deth RC et al. Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. Nutrition. 2013;29(9):1142-1146.

Bent S, Bertoglio K, Ashwood P et al. A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder. J Autism Dev Disord. 2011 May;41(5):545-54. FULL TEXT

Cognitive decline

Stilling F, Wolk A, Religa D, Leppert J, Bergkvist L, Michaëlsson K, et al. Adipose tissue fatty acid composition and cognitive impairment. Nutrition. 2018;54:153-7.

McNamara RK, Kalt W, Shidler MD, McDonald J, Summer SS, Stein AL, et al. Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment. Neurobiol Aging. 2018;64:147-56.

Pérez-Gálvez A, Jarén-Galán M, Garrido-Fernández J, Calvo MV, Visioli F, Fontecha J. Activities, bioavailability, and metabolism of lipids from structural membranes and oils: Promising research on mild cognitive impairment. Pharmacol Res. 2018 Jul 20;134:299-304.

Famenini S, Rigali EA, Olivera-Perez HM, Dang J, Chang MT, Halder R, Rao RV, Pellegrini M, Porter V, Bredesen D, Fiala M. Increased intermediate M1-M2 macrophage polarization and improved cognition in mild cognitive impairment patients on ω-3 supplementation. FASEB J. 2017 Jan;31(1):148-160. FULL TEXT

Cutuli D. Functional and structural benefits induced by omega-3 polyunsaturated fatty acids during aging. Curr Neuropharmacol. 2016 Jun 13. [Epub ahead of print]

Hashimoto M, Kato S, Tanabe Y et al. Beneficial effects of dietary docosahexaenoic acid intervention on cognitive function and mental health of the oldest elderly in Japanese care facilities and nursing homes. Geriatr Gerontol Int. 2016 Jan 28. doi: 10.1111/ggi.12691. [Epub ahead of print]

Oulhaj A, Jernerén F, Refsum H et al. Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. J Alzheimers Dis. 2016 Jan 6. [Epub ahead of print] FULL TEXT

Köbe T, Witte AV, Schnelle A, Lesemann A, Fabian S, Tesky VA, Pantel J, Flöel A. Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. Neuroimage. 2015 Oct 1. pii: S1053-8119(15)00872-1.

Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015 Jul;102(1):215-21.

Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015 Jul;102(1):215-21.

Rathod RS, Khaire AA, Kale AA, Joshi SR. Beneficial effects of omega-3 fatty acids and vitamin B12 supplementation on brain docosahexaenoic acid, brain derived neurotrophic factor, and cognitive performance in the second-generation Wistar rats. Biofactors. 2015 Jul-Aug;41(4):261-72.

Lorente-Cebrián S, Costa AG, Navas-Carretero S, Zabala M, Laiglesia LM, Martínez JA, Moreno-Aliaga MJ. An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases. J Physiol Biochem. 2015 Jun;71(2):341-9. doi: 10.1007/s13105-015-0395-y.

Pusceddu MM, Kelly P, Ariffin N, Cryan JF, Clarke G, Dinan TG. n-3 PUFAs have beneficial effects on anxiety and cognition in female rats: Effects of early life stress. Psychoneuroendocrinology. 2015 Apr 28;58:79-90. doi: 10.1016/j.psyneuen.2015.04.015.

Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015 Apr 15. pii: ajcn103283.

Dehkordi NG, Noorbakhshnia M, Ghaedi K, Esmaeili A, Dabaghi M. Omega-3 fatty acids prevent LPS-induced passive avoidance learning and memory and CaMKII-α gene expression impairments in hippocampus of rat. Pharmacol Rep. 2015 Apr;67(2):370-5. doi: 10.1016/j.pharep.2014.10.014.

Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, Bredesen DE. ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB J. 2015 Jul;29(7):2681-9. doi: 10.1096/fj.14-264218. Epub 2015 Mar 24.

Chang PK, Khatchadourian A, McKinney RA, Maysinger D. Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology. J Neuroinflammation. 2015 Dec;12(1):244. doi: 10.1186/s12974-015-0244-5. FULL TEXT

Street SJ, Parletta N, Milte C, Sullivan K, Hills AP, Buckley J, Howe P. Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment. Aging Ment Health. 2015 Oct;19(10):885-91. doi: 10.1080/13607863.2014.971705. Epub 2014 Nov 6.

Abdel-Wahab BA, Al-Qahtani JM, El-Safty SA. Omega-3 polyunsaturated fatty acids in large doses attenuate seizures, cognitive impairment, and hippocampal oxidative DNA damage in young kindled rats. Neurosci Lett. 2014 Oct 11. pii: S0304-3940(14)00806-4.

Grayson DS, Kroenke CD, Neuringer M, Fair DA. Dietary Omega-3 Fatty Acids Modulate Large-Scale Systems Organization in the Rhesus Macaque Brain. J Neurosci. 2014 Feb 5;34(6):2065-74. doi: 10.1523/JNEUROSCI.3038-13.2014. FULL TEXT

Wiesmann M, Kiliaan AJ, Claassen JA. Vascular aspects of cognitive impairment and dementia. J Cereb Blood Flow Metab. 2013 Nov;33(11):1696-706. FULL TEXT

O’Callaghan N, Parletta N, Milte CM et al. Telomere shortening in elderly people with mild cognitive impairment may be attenuated with omega-3 fatty acid supplementation: A randomised controlled pilot study. Nutrition. Available online 3 October 2013.In Press, Accepted Manuscript.

O’Callaghan N, Parletta N, Milte CM et al. Telomere shortening in elderly people with mild cognitive impairment may be attenuated with omega-3 fatty acid supplementation: A randomised controlled pilot study. Nutrition. Available online 3 October 2013.In Press, Accepted Manuscript.

Witte AV, Kerti L, Hermannstädter HM et al. Long-Chain Omega-3 Fatty Acids Improve Brain Function and Structure in Older Adults. Cereb Cortex. 2013 Jun 24.

Denis I, Potier B, Vancassel S, Heberden C, Lavialle M. Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. Ageing Res Rev. 2013 Mar;12(2):579-94.

Avramovic N, Dragutinovic V, Krstic D et al. The effects of omega 3 fatty acid supplementation on brain tissue oxidative status in aged wistar rats. Hippokratia. 2012 Jul;16(3):241-5. FULL TEXT

Nilsson A, Radeborg K, Salo I et al. Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study. Nutr J 2012;11:99. FULL TEXT

Bowman GL, Silbert LC, Howieson D, Dodge HH, Traber MG, Frei B, Kaye JA, Shannon J, Quinn JF. Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Neurology. 2012; 78:241-249. FULL TEXT

Tan ZS, Harris WS, Beiser AS et al. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology. 2012; 78:658-664.

Samieri C, Maillard P, Crivello F, Proust-Lima C, Peuchant E, Helmer C, Amieva H, Allard M, Dartigues JF, Cunnane SC, Mazoyer BM, Barberger-Gateau P. Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe. Neurology. 2012; 79:642-650.

Matesanz N, Park G, McAllister H et al. Docosahexaenoic acid improves the nitroso-redox balance and reduces VEGF-mediated angiogenic signaling in microvascular endothelial cells. Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6815-25.

Yurko-Mauro K, McCarthy D, Rom D et al. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement. 2010 Nov;6(6):456-64. doi: 10.1016/j.jalz.2010.01.013.

Zhang F, Yang H, Pan Z et al. Dependence of resolvin-induced increases in corneal epithelial cell migration on EGF receptor transactivation. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5601-9. FULL TEXT

Yurko-Mauro K, McCarthy D, Rom D et al. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement. 2010 Nov;6(6):456-64. doi: 10.1016/j.jalz.2010.01.013.

Marszalek JR, Lodish HF. Docosahexaenoic acid, fatty acid-interacting proteins and neural function. Annual Review of Cell and Development Biology 2005; 21: 633-657.

Cenacchi T, Bertoldin T, Farina C, Fiori MG, Crepaldi G. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging Clin Exp Res 1993; 5: 123-33.

Cystic fibrosis

Dementia and Alzheimer

Zhu M, Wang X, Hjorth E, et al. Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis. Mol Neurobiol. 2016;53(4):2733-49.

Shang J, Yamashita T, Fukui Y, Song D, Li X, Zhai Y, et al. Different Associations of Plasma Biomarkers in Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, and Ischemic Stroke. J Clin Neurol. 2018;14(1):29-34.

Derbyshire E. Brain health across the lifespan: a systematic review on the role of omega-3 fatty acid supplements. Nutrients. 2018 Aug 15;10(8).

van Lent DM, Weinhold L, Wolfsgruber S, Schmid M, Maier W, Jessen F, et al. Eicosapentanoic acid but not docosahexaenoic acid is associated with Alzheimer's disease risk in the oldest old. Presented at: 2018 Alzheimer's Association International Conference. July 22-26, 2018; Chicago, IL. Abstract 22855

Wang L, Fan H, He J, Wang L, Tian Z, Wang C. Protective effects of omega-3 fatty acids against Alzheimer's disease in rat brain endothelial cells. Brain Behav. 2018 Oct 8:e01037. doi: 10.1002/brb3.1037. [Epub ahead of print]

Impaired Resolution of Inflammation in Alzheimer’s Disease: A Review Robert A. Whittington, Emmanuel Planel and Niccolò Terrando

Ammann EM, Pottala JV, Robinson JG, Espeland MA, Harris WS. Erythrocyte omega-3 fatty acids are inversely associated with incident dementia: Secondary analyses of longitudinal data from the Women's Health Initiative Memory Study (WHIMS). Prostaglandins Leukot Essent Fatty Acids. 2017;121:68-75.

Nock TG, Chouinard-Watkins R, Plourde M. Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline. Biochim Biophys Acta. 2017 Jul 18;1862(10 Pt A):1068-1078.

Grimm MO, Michaelson D, Hartmann T. Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention. J Lipid Res. 2017 May 20. FULL TEXT

Fiala M, Kooij G, Wagner K et al. Modulation of innate immunity of patients with Alzheimer's disease by omega-3 fatty acids. FASEB J. 2017 Apr 18.

Yassine HN, Braskie MN, Mack WJ, Castor KJ, Fonteh AN, Schneider LS, Harrington MG, Chui HC. Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers: A Review. JAMA Neurol. 2017 Mar 1;74(3):339-347.

Yanai H. Effects of N-3 Polyunsaturated Fatty Acids on Dementia. J Clin Med Res. 2017 Jan;9(1):1-9. FULL TEXT

Ren H, Luo C, Feng Y Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su H. Omega-3 polyunsaturated fatty acids promote amyloid-β clearance from the brain through mediating the function of the glymphatic system. FASEB J. 2017 Jan;31(1):282-293.

Grimm MO, Mett J, Stahlmann CP, Haupenthal VJ, Blümel T, Stötzel H, Grimm HS, Hartmann T. Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme. Biochem Cell Biol. 2016 Dec;94(6):534-542.

Belkouch M, Hachem M, Elgot A, Lo Van A, Picq M, Guichardant M, Lagarde M, Bernoud-Hubac N. The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease. J Nutr Biochem. 2016 Dec;38:1-11.

Eriksdotter M, Vedin I, Falahati F, Freund-Levi Y, Hjorth E, Faxen-Irving G, Wahlund LO, Schultzberg M, Basun H, Cederholm T, Palmblad J. Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer's Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study. J Alzheimers Dis. 2015 Oct 1;48(3):805-12.

Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, Bredesen DE. ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB J. 2015 Jul;29(7):2681-9.

Casali BT, Corona AW, Mariani MM, Karlo JC, Ghosal K, Landreth GE. Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015 Jun 17;35(24):9173-81.

Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, Bredesen DE. ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB J. 2015 Mar 24. pii: fj.14-264218.

Shinto L, Quinn J, Montine T, Dodge HH, Woodward W, Baldauf-Wagner S, Waichunas D, Bumgarner L, Bourdette D, Silbert L, Kaye J. A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease. J Alzheimers Dis. 2014;38(1):111-20. doi: 10.3233/JAD-130722. FULL TEXT

Wiesmann M, Kiliaan AJ, Claassen JA. Vascular aspects of cognitive impairment and dementia. J Cereb Blood Flow Metab. 2013 Nov;33(11):1696-706. FULL TEXT

Zhao Y, Calon F, Julien C et al. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPAR?-mediated mechanisms in Alzheimer's disease models. PLoS One. 2011 Jan 5;6(1):e15816. FULL TEXT

Caballer García J. Los ácidos grasos omega-3 en la prevención de la enfermedad de Alzheimer. Alzheimer. Real Invest Demenc. 2011;49:12-18. FULL TEXT

Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C, Galvin JE, Emond J, Jack CR Jr, Weiner M, Shinto L, Aisen PS. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA. 2010 Nov 3;304(17):1903-11. FULL TEXT

Jicha GA, Markesbery WR. Omega-3 fatty acids: potential role in the management of early Alzheimer's disease. Clin Interv Aging. 2010 Apr 7;5:45-61. FULL TEXT

Fotuhi M, Mohassel P, Yaffe K. Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association. Nat Clin Pract Neurol. 2009 Mar;5(3):140-52.

Palmblad J, Eriksdotter-Jönhagen M, Freund-Levi Y, Cederholm T. Omega-3-fatty acids protect against dementia. Also early symptoms of mild Alzheimer disease seem to be inhibited. Lakartidningen. 2007 Oct 31-Nov 6;104(44):3268-71.

Epilepsy

Memory

Zamroziewicz MK, Paul EJ, Zwilling CE, et al. Predictors of Memory in Healthy Aging: Polyunsaturated Fatty Acid Balance and Fornix White Matter Integrity. Aging Dis. 2017 Jul 21;8(4):372-83. FULL TEXT

Külzow N, Witte AV, Kerti L et al. Impact of Omega-3 Fatty Acid Supplementation on Memory Functions in Healthy Older Adults. J Alzheimers Dis. 2016 Feb 10. [Epub ahead of print]

Boespflug EL, McNamara RK, Eliassen JC et al. Fish Oil Supplementation Increases Event-Related Posterior Cingulate Activation in Older Adults with Subjective Memory Impairment. J Nutr Health Aging. 2016;20(2):161-9. doi: 10.1007/s12603-015-0609-6.

Gharami K, Das M, Das S. Essential role of docosahexaenoic acid towards development of a smarter brain. Neurochem Int. 2015 Oct;89:51-62.

Nilsson A, Radeborg K, Salo I et al. Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study. Nutr J 2012;11:99. FULL TEXT

Vakhapova V, Cohen T, Richter Y, Herzog Y, Korczyn AD. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. Dement Geriatr Cogn Disord. 2010;29(5):467-74.

Frais AT. Depression and the causal role of specific memory system degenerations: link may be supported by reported therapeutic benefits of Omega 3 fatty acids. Med Hypotheses. 2007;69(1):67-9.

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