Studies

Miscellany

Chiu YH, Karmon AE, Gaskins AJ, et al; EARTH Study Team. Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction. Hum Reprod. 2017:1-10.

Viecelli AK, Mori TA, Roy-Chaudhury P, et al. The pathogenesis of hemodialysis vascular access failure and systemic therapies for its prevention: Optimism unfulfilled. Semin Dial. 2017 Nov 26.

Levental KR, Surma MA, Skinkle AD, et al. ω-3 polyunsaturated fatty acids direct differentiation of the membrane phenotype in mesenchymal stem cells to potentiate osteogenesis. Sci Adv. 2017 Nov 8;3(11):eaao1193. eCollection 2017 Nov.

Watson H, Mitra S, Croden FC, et al. A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota. Gut. 2017 Sep 26.

Menni C, Zierer J, Pallister T, et al. Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women. Sci Rep. 2017 Sep 11;7(1):11079.

Kuroda T, Ohta H, Onoe Y, Tsugawa N, Shiraki M. Intake of omega-3 fatty acids contributes to bone mineral density at the hip in a younger Japanese female population. Osteoporos Int. 2017 Jun 23. [Epub ahead of print]

Allaire J, Harris WS, Vors C et al. Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid. Prostaglandins Leukot Essent Fatty Acids. 2017 May;120:8-14.

Harris WS, Luo J, Pottala JV, Espeland MA, Margolis KL, Manson JE, Wang L, Brasky TM, Robinson JG. Red blood cell polyunsaturated fatty acids and mortality in the women’s health initiative memory study. Journal of Clinical Lipidology. 2017.

Martínez-Ordaz JL, Boscó-Gárate I, Cérbulo-Vázquez A, Arriaga-Pizano L, Wong-Baeza I, Sánchez-Fernandez P, López-Macías C, Isibasi A, Ferat-Osorio E. Effect of Oral ω3-Polyunsaturated Fatty Acids as a Complement Management to Control Fistula Output and Inflammation in Patients With Digestive Fistula. J Gastrointest Surg. 2017 Mar;21(3):453-462.

Wiest EF, Walsh-Wilcox MT, Walker MK. Omega-3 Polyunsaturated Fatty Acids Protect against Cigarette Smoke-Induced Oxidative Stress and Vascular Dysfunction. Toxicol Sci. 2017 Jan 22.

Mirabi P, Chaichi MJ, Esmaeilzadeh S, Ali Jorsaraei SG, Bijani A, Ehsani M, Hashemi Karooee SF. The role of fatty acids on ICSI outcomes: a prospective cohort study. Lipids Health Dis. 2017 Jan 21;16(1):18. FULL TEXT

Kim HJ, Ohk B, Yoon HJ, Kang WY, Seong SJ, Kim SY, Yoon YR. Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts. Cell Signal. 2017 Jan;29:226-232.

Casas-Agustench P, Cherubini A, Andrés-Lacueva C. Lipids and physical function in older adults. Curr Opin Clin Nutr Metab Care. 2017 Jan;20(1):16-25.

Nouri K, Walch K, Weghofer A, Imhof M, Egarter C, Ott J. The Impact of a Standardized Oral Multinutrient Supplementation on Embryo Quality in in vitro Fertilization/Intracytoplasmic Sperm Injection: A Prospective Randomized Trial. Gynecol Obstet Invest. 2017;82(1):8-14.

Moore BF, Clark ML, Bachand A, Reynolds SJ, Nelson TL, Peel JL. Interactions between Diet and Exposure to Secondhand Smoke on Glycated Hemoglobin (HbA1c) Levels among U.S. Children: Results from NHANES 2007-2012. Nicotine Tob Res. 2016 Sep 27. pii: ntw261. [Epub ahead of print]

Pasternak A, Bugajska J, Szura M, Walocha JA, Matyja A, Gajda M, Sztefko K, Gil K. Biliary polyunsaturated fatty acids and telocytes in gallstone disease. Cell Transplant. 2016 Aug 5. [Epub ahead of print]

Robertson RC, Seira Oriach C, Murphy K, Moloney GM, Cryan JF, Dinan TG, Paul Ross R, Stanton C. Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood. Brain Behav Immun. 2016 Jul 14. pii: S0889-1591(16)30339-7. doi: 10.1016/j.bbi.2016.07.145. [Epub ahead of print]

Lewis MD. Concussions, Traumatic Brain Injury, and the Innovative Use of Omega-3s. J Am Coll Nutr. 2016 Jul;35(5):469-75. doi: 10.1080/07315724.2016.1150796.

Sorto-Gomez TE, Ortiz GG, Pacheco-Moises FP, Torres-Sanchez ED, Ramirez-Ramirez V, Macias-Islas MA, de la Rosa AC, Velázquez-Brizuela IE. Effect of fish oil on glutathione redox system in multiple sclerosis. Am J Neurodegener Dis. 2016 Jun 1;5(2):145-51. eCollection 2016. FULL TEXT

Ter Borg S, de Groot LC, Mijnarends DM et al. Differences in Nutrient Intake and Biochemical Nutrient Status Between Sarcopenic and Nonsarcopenic Older Adults-Results From the Maastricht Sarcopenia Study. J Am Med Dir Assoc. 2016 Jan 26. pii: S1525-8610(15)00765-3. doi: 10.1016/j.jamda.2015.12.015. [Epub ahead of print] FULL TEXT

Ter Borg S, de Groot LC, Mijnarends DM et al. Differences in Nutrient Intake and Biochemical Nutrient Status Between Sarcopenic and Nonsarcopenic Older Adults-Results From the Maastricht Sarcopenia Study. J Am Med Dir Assoc. 2016 Jan 26. pii: S1525-8610(15)00765-3. doi: 10.1016/j.jamda.2015.12.015. [Epub ahead of print] FULL TEXT

Smith GI, Julliand S, Reeds DN, Sinacore DR, Klein S, Mittendorfer B. Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr. 2015 Jul;102(1):115-22.

Li R, Sabir JS, Baeshen NA, Akoh CC. Enzymatic Synthesis of Refined Olive Oil-Based Structured Lipid Containing Omega -3 and -6 Fatty Acids for Potential Application in Infant Formula. J Food Sci. 2015 Nov;80(11):H2578-84.

Xiao G, Yuan F, Geng Y, Qiu X, Liu Z, Lu J, Tang L, Zhang Y, Su L. Eicosapentaenoic Acid Enhances Heat Stroke-impaired Intestinal Epithelial Barrier Function in Rats. Shock. 2015 Oct;44(4):348-56.

Crawford MA, Wang Y, Forsyth S, Brenna JT. The European Food Safety Authority recommendation for polyunsaturated fatty acid composition of infant formula overrules breast milk, puts infants at risk, and should be revised. Prostaglandins Leukot Essent Fatty Acids. 2015 Dec;102-103:1-3.

Yurko-Mauro K, Kralovec J, Bailey-Hall E, Smeberg V, Stark JG, Salem N Jr. Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study. Lipids Health Dis. 2015 Sep 2;14:99. FULL TEXT

Sabour H, Norouzi Javidan A, Latifi S, Shidfar F, Heshmat R, Emami Razavi SH, Vafa MR, Larijani B. Omega-3 fatty acids' effect on leptin and adiponectin concentrations in patients with spinal cord injury: A double-blinded randomized clinical trial. J Spinal Cord Med. 2015 Sep;38(5):599-606.

Delfan M, Ebrahim K, Baesi F, Mirakhori Z, Ghalamfarsa G, Bakhshaei P, Saboor-Yaraghi AA, Razavi A, Setayesh M, Yousefi M, Jadidi-Niaragh F. The immunomodulatory effects of fish-oil supplementation in elite paddlers: A pilot randomized double blind placebo-controlled trial. Prostaglandins Leukot Essent Fatty Acids. 2015 Aug;99:35-40.

Ruiz-Lopez N, Stubhaug I, Ipharraguerre I, Rimbach G, Menoyo D. Positional Distribution of Fatty Acids in Triacylglycerols and Phospholipids from Fillets of Atlantic Salmon (Salmo Salar) Fed Vegetable and Fish Oil Blends. Mar Drugs. 2015 Jul 10;13(7):4255-69. FULL TEXT

Betancor MB, Sprague M, Sayanova O, Usher S, Campbell PJ, Napier JA, Caballero MJ, Tocher DR. Evaluation of a high-EPA oil from transgenic Camelina sativa in feeds for Atlantic salmon (Salmo salar L.): Effects on tissue fatty acid composition, histology and gene expression. Aquaculture. 2015 Jul 1;444:1-12. FULL TEXT

Salunke D, Manglekar R, Gadre R, Nene S, Harsulkar AM. Production of polyunsaturated fatty acids in recombinant Lipomyces starkeyi through submerged fermentation. Bioprocess Biosyst Eng. 2015 Jul;38(7):1407-14.

Delplanque B, Gibson R, Koletzko B, Lapillonne A, Strandvik B. Lipid Quality in Infant Nutrition: Current Knowledge and Future Opportunities. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):8-17.

Roy J, Le Guennec JY, Galano JM, Thireau J, Bultel-Poncé V, Demion M, Oger C, Lee JC, Durand T. Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs? Biochimie. 2015 Jun 23. pii: S0300-9084(15)00181-9. doi: 10.1016/j.biochi.2015.06.010.

Lewis EJH, Radonic PW, Wolever TMS, Wells GD. 21 days of mammalian omega-3 fatty acid supplementation improves aspects of neuromuscular function and performance in male athletes compared to olive oil placebo. J Int Soc Sports Nutr. 2015 Jun 18;12:28. FULL TEXT

Smith G, Julliand S, Reeds DN, Sinacore DR, Klein S, Mittendorfer B. Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr. 2015 May 20. pii: ajcn105833.

Wagner A, Simon C, Morio B, Dallongeville J, Ruidavets JB, Haas B, Laillet B, Cottel D, Ferrières J, Arveiler D. Omega-3 index levels and associated factors in a middle-aged French population: the MONA LISA-NUT Study. Eur J Clin Nutr. 2015 Apr;69(4):436-41 doi:10.1038/ejcn.2014.219

Algae

Alpha-linolenic acid

Chronic kidney disease

Roach LA, Lambert K, Holt JL, et al. Diet quality in patients with end-stage kidney disease undergoing dialysis. J Ren Care. 2017 Sep 24.

Pandurangan M, Enkhtaivan G, Veerappan M, et al. Renal-protective and ameliorating impacts of omega-3 fatty acids against aspartame damaged MDCK cells. Biofactors. 2017 Sep 7.

Zanetti M, Gortan Cappellari G, Barbetta D, et al. Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress. Nutrients. 2017 Aug 18;9(8).

Gomes Neto AW, Sotomayor Campos CG, Pranger IG et al. Intake of Marine-Derived Omega-3 Polyunsaturated Fatty Acids and Mortality in Renal Transplant Recipients. Nutrients. 2017 Apr 5;9(4). FULL TEXT

Hirahashi J. Omega-3 Polyunsaturated Fatty Acids for the Treatment of IgA Nephropathy. J Clin Med. 2017 Jul 19;6(7). FULL TEXT

Elajami TK, Alfaddagh A, Lakshminarayan D, Soliman M, Chandnani M, Welty FK. Eicosapentaenoic and Docosahexaenoic Acids Attenuate Progression of Albuminuria in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease. J Am Heart Assoc. 2017 Jul 14;6(7). FULL TEXT

Navaneethan SD, Virani SS. Omega-3 Fatty Acids (Fish Oil) Supplementation and Albuminuria: Not a Slam Dunk. J Am Heart Assoc. 2017 Jul 14;6(7). FULL TEXT

Zeng Z, Yang H, Wang Y et al. Omega-3 Polyunsaturated Fatty Acids Attenuate Fibroblast Activation and Kidney Fibrosis Involving MTORC2 Signaling Suppression. Sci Rep. 2017 Apr 10;7:46146. FULL TEXT

de Mattos AM, da Costa JAC, Jordão Júnior AA et al. Omega-3 Fatty Acid Supplementation is Associated With Oxidative Stress and Dyslipidemia, but Does not Contribute to Better Lipid and Oxidative Status on Hemodialysis Patients. J Ren Nutr. 2017 Apr 20.

Ateya AM, Sabri NA, El Hakim I, Shaheen SM. Effect of Omega-3 Fatty Acids on Serum Lipid Profile and Oxidative Stress in Pediatric Patients on Regular Hemodialysis: A Randomized Placebo-Controlled Study. J Ren Nutr. 2017 Jan 16. pii: S1051-2276(16)30180-7. doi: 10.1053/j.jrn.2016.11.005. [Epub ahead of print]

Xu T, Sun Y, Sun W, Yao L, Sun L, Liu L, Ma J, Wang L. Effect of omega-3 fatty acid supplementation on serum lipids and vascular inflammation in patients with end-stage renal disease: a meta-analysis. Sci Rep. 2016 Dec 23;6:39346. FULL TEXT

Panahi Y, Dashti-Khavidaki S, Farnood F, Noshad H, Lotfi M, Gharekhani A. Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review. Adv Pharm Bull. 2016 Dec;6(4):509-514. FULL TEXT

Asemi Z, Soleimani A, Shakeri H, Mazroii N, Esmaillzadeh A. Effects of omega-3 fatty acid plus alpha-tocopherol supplementation on malnutrition-inflammation score, biomarkers of inflammation and oxidative stress in chronic hemodialysis patients. Int Urol Nephrol. 2016 Aug 23. [Epub ahead of print]

Deger SM, Hung AM, Ellis CD, Booker C, Bian A, Chen G, Abumrad NN, Ikizler TA. High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients. Clin J Am Soc Nephrol. 2016 Jul 7;11(7):1227-35. doi: 10.2215/CJN.04150415. Epub 2016 Jun 8.

Deger SM, Hung AM, Ellis CD et al. High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients. Clin J Am Soc Nephrol. 2016 Jun 8. pii: CJN.04150415. [Epub ahead of print]

Umemoto N, Ishii H, Kamoi D et al. Reverse association of omega-3/omega-6 polyunsaturated fatty acids ratios with carotid atherosclerosis in patients on hemodialysis. Atherosclerosis. 2016 Apr 1;249:65-69. doi: 10.1016/j.atherosclerosis.2016.03.037. [Epub ahead of print]

Barden AE, Burke V, Mas E, Beilin LJ, Puddey IB, Watts GF, Irish AB, Mori TA. n-3 fatty acids reduce plasma 20-hydroxyeicosatetraenoic acid and blood pressure in patients with chronic kidney disease. J Hypertens. 2015 Sep;33(9):1947-53.

Viecelli AK, Pascoe E, Polkinghorne KR, Hawley C, Paul-Brent PA, Badve SV, Cass A, Heritier S, Kerr PG, Mori TA, Robertson A, Seong HL, Irish AB; FAVOURED study team. The Omega-3 fatty acids (Fish Oils) and Aspirin in Vascular access OUtcomes in REnal Disease (FAVOURED) study: the updated final trial protocol and rationale of post-initiation trial modifications. BMC Nephrol. 2015 Jun 27;16:89. FULL TEXT

Hirahashi J, Hanafusa N, Wada T, Arita M, Hishikawa K, Hayashi M, Nangaku M. Aspirin and Eicosapentaenoic Acid May Arrest Progressive IgA Nephropathy: A Potential Alternative to Immunosuppression. Intern Med. 2015;54(18):2377-82. FULL TEXT

Lee SM, An WS. Cardioprotective effects of ? -3 PUFAs in chronic kidney disease. Biomed Res Int. 2013;2013:712949. FULL TEXT

Chronic obstructive pulmonary disease

Emulsions

Shinde RL, Bharkad GP, Devarajan PV. Intranasal microemulsion for targeted nose to brain delivery in neurocysticercosis: Role of docosahexaenoic acid. Eur J Pharm Biopharm. 2015 Oct;96:363-79.

Manzanares W, Langlois PL. Fish oil containing lipid emulsions in critically ill patients: Critical analysis and future perspectives. Med Intensiva. 2015 Sep 21. pii: S0210-5691(15)00165-5.

Skouroliakou M, Konstantinou D, Agakidis C, Kaliora A, Kalogeropoulos N, Massara P, Antoniadi M, Panagiotakos D, Karagiozoglou-Lampoudi T. Parenteral MCT/ω-3 Polyunsaturated Fatty Acid-Enriched Intravenous Fat Emulsion Is Associated With Cytokine and Fatty Acid Profiles Consistent With Attenuated Inflammatory Response in Preterm Neonates: A Randomized, Double-Blind Clinical Trial. Nutr Clin Pract. 2015 Sep 16.

Linecker M, Limani P, Botea F, Popescu I, Alikhanov R, Efanov M, Kim P, Khatkov I, Raptis DA, Tschuor C, Beck-Schimmer B, Bonvini J, Wirsching A, Kron P, Slankamenac K, Humar B, Graf R, Petrowsky H, Clavien PA. A randomized, double-blind study of the effects of omega-3 fatty acids (Omegaven™) on outcome after major liver resection. BMC Gastroenterol. 2015 Aug 14;15:102. FULL TEXT

Goyal A, Sharma V, Upadhyay N, Singh AK, Arora S, Lal D, Sabikhi L. Development of stable flaxseed oil emulsions as a potential delivery system of ω-3 fatty acids. J Food Sci Technol. 2015 Jul;52(7):4256-65.

Trépanier MO, Kwong KM, Domenichiello AF, Chen CT, Bazinet RP, Burnham WM. Intravenous infusion of docosahexaenoic acid increases serum concentrations in a dose-dependent manner and increases seizure latency in the maximal PTZ model. Epilepsy Behav. 2015 Jun 30;50:71-76.

Wu GH, Gao J, Ji CY, Pradelli L, Xi QL, Zhuang QL. Cost and effectiveness of omega-3 fatty acid supplementation in Chinese ICU patients receiving parenteral nutrition. Clinicoecon Outcomes Res. 2015 Jun 26;7:369-75. FULL TEXT

Zugasti Murillo A, Petrina Jáuregui E, Elizondo Armendáriz J. Parenteral nutrition-associated liver disease and lipid emulsions. Endocrinol Nutr. 2015 Jun-Jul;62(6):285-9.

Zugasti Murillo A, Petrina Jáuregui E, Elizondo Armendáriz J. Parenteral nutrition-associated liver disease and lipid emulsions. Endocrinol Nutr. 2015 May 13. pii: S1575-0922(15)00094-7. doi: 10.1016/j.endonu.2015.03.008.

Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K. Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial. Crit Care. 2015 May 12;19(1):226. doi: 10.1186/s13054-015-0933-6.

Esquerdo VM, Dotto GL, Pinto LA. Preparation of nanoemulsions containing unsaturated fatty acid concentrate-chitosan capsules. J Colloid Interface Sci. 2015 May 1;445:137-42. doi: 10.1016/j.jcis.2014.12.094.

Cavazos-Garduño A, Ochoa Flores AA, Serrano-Niño JC, Martínez-Sanchez CE, Beristain CI, García HS. Preparation of betulinic acid nanoemulsions stabilized by ω-3 enriched phosphatidylcholine. Ultrason Sonochem. 2015 May;24:204-13. doi: 10.1016/j.ultsonch.2014.12.007.

Manzanares W, Langlois PL, Dhaliwal R, Lemieux M, Heyland DK. Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis. Crit Care. 2015 Apr 16;19(1):167. doi: 10.1186/s13054-015-0888-7.

Vestland TL, Jacobsen Ø, Sande SA, Myrset AH, Klaveness J. Compactible powders of omega-3 and β-cyclodextrin. Food Chem. 2015 Oct 15;185:151-8. doi: 10.1016/j.foodchem.2015.03.132. Epub 2015 Apr 4.

Turner JM, Josephson J, Field CJ, Wizzard PR, Ball RO, Pencharz PB, Wales PW. Liver Disease, Systemic Inflammation, and Growth Using a Mixed Parenteral Lipid Emulsion, Containing Soybean Oil, Fish Oil, and Medium Chain Triglycerides, Compared With Soybean Oil in Parenteral Nutrition-Fed Neonatal Piglets. JPEN J Parenter Enteral Nutr. 2015 Apr 2. pii: 0148607115579711.

Divya Erattea, Stafford McKnighta, Thomas R. Gengenbachb, Kim Dowlinga, Colin J. Barrow, Benu P. Adhikarid. Co-encapsulation and characterisation of omega-3 fatty acids and probiotic bacteria in whey protein isolate–gum Arabic complex. Journal of Functional Foods. online 16 February 2015.

Böttcher S, Steinhäuser U, Drusch S. Off-flavour masking of secondary lipid oxidation products by pea dextrin. Food Chem. 2015 Feb 15;169:492-8. doi: 10.1016/j.foodchem.2014.05.006.

Larsen BM, Field CJ, Leong AY, Goonewardene LA, Van Aerde JE, Joffe AR, Clandinin MT. Pretreatment with an intravenous lipid emulsion increases plasma eicosapentanoic acid and downregulates leukotriene b4, procalcitonin, and lymphocyte concentrations after open heart surgery in infants. JPEN J Parenter Enteral Nutr. 2015 Feb;39(2):171-9. doi: 10.1177/0148607113505326. Epub 2013 Oct 11.

Wang B, Vongsvivut J, Adhikari B, Barrow CJ. Microencapsulation of tuna oil fortified with the multiple lipophilic ingredients vitamins A, D3, E, K2, curcumin and coenzyme Q10. Journal of Functional Foods. 2015.

Biagetti C, Vedovelli L, Savini S, Simonato M, D'Ascenzo R, Pompilio A, Cogo PE, Carnielli VP. Double blind exploratory study on de novo lipogenesis in preterm infants on parenteral nutrition with a lipid emulsion containing 10% fish oil. Clin Nutr. 2015 Apr 12. pii: S0261-5614(15)00103-X. doi: 10.1016/j.clnu.2015.04.005.

Glomerulonephritis

Hepatic

Gibson PS, Lang S, Dhawan A, et al. Systematic Review: Nutrition and Physical Activity in the Management of Paediatric Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr. 2017;65(2):141-9.

Hodson L, Bhatia L, Scorletti E, et al. Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study. Eur J Clin Nutr. 2017;71(8):973-9.

Firat O, Makay O, Yeniay L, Gokce G, Yenisey C, Coker A. Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration. Ann Surg Treat Res. 2017 Jul;93(1):1-10. FULL TEXT

Jump DB, Lytle KA, Depner CM, Tripathy S. Omega-3 Polyunsaturated Fatty Acids as a Treatment Strategy for Nonalcoholic Fatty Liver Disease. Pharmacol Ther. 2017 Jul 16. [Epub ahead of print]

Jung TW, Kim HC, Abd El-Aty AM, Jeong JH. Protectin DX suppresses hepatic gluconeogenesis through AMPK-HO-1-mediated inhibition of ER stress. Cell Signal. 2017 Jun;34:133-40.

Wang C, Liu W, Yao L et al. Hydroxyeicosapentaenoic Acids and Epoxyeicosatetraenoic Acids Attenuate Early Occurrence of Nonalcoholic Fatty Liver Disease. Br J Pharmacol. 2017 May 4.

Al-Attar AM, Al-Rethea HA. Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats. Saudi J Biol Sci. 2017 May;24(4):956-965. FULL TEXT

Gibson PS, Lang S, Dhawan A et al. Systematic Review: Nutrition and Physical Activity in the Management of Paediatric Non-alcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr. 2017 May 9.

Lytle KA, Wong CP, Jump DB. Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice. PLoS One. 2017 Apr 19;12(4):e0173376. FULL TEXT

de Castro GS, Calder PC. Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids. Clin Nutr. 2017 Jan 19.

Chen LH, Wang YF, Xu QH, Chen SS. Omega-3 fatty acids as a treatment for non-alcoholic fatty liver disease in children: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2016 Dec 23. pii: S0261-5614(16)31350-4. doi: 10.1016/j.clnu.2016.12.009. [Epub ahead of print]

Jun WY, Cho MJ, Han HS, Bae SH. Use of Omega-3 Polyunsaturated Fatty Acids to Treat Inspissated Bile Syndrome: A Case Report. Pediatr Gastroenterol Hepatol Nutr. 2016 Dec;19(4):286-290. FULL TEXT

Gomaa AM, Abd El-Aziz EA. Omega-3 fatty acids decreases oxidative stress, tumor necrosis factor-alpha, and interleukin-1 beta in hyperthyroidism-induced hepatic dysfunction rat model. Pathophysiology. 2016 Dec;23(4):295-301.

Kobyliak N, Falalyeyeva T, Bodnar P, Beregova T. Probiotics Supplemented with Omega-3 Fatty Acids are More Effective for Hepatic Steatosis Reduction in an Animal Model of Obesity. Probiotics Antimicrob Proteins. 2016 Sep 22. [Epub ahead of print]

Li Y, Tang Y, Wang S, Zhou J, Zhou J, Lu X, Bai X, Wang XY, Chen Z, Zuo D. Endogenous n-3 Polyunsaturated Fatty Acids Attenuate T Cell-Mediated Hepatitis via Autophagy Activation. Front Immunol. 2016 Sep 13;7:350. doi: 10.3389/fimmu.2016.00350. eCollection 2016. FULL TEXT

Lu W, Li S, Li J, Wang J, Zhang R, Zhou Y, Yin Q, Zheng Y, Wang F, Xia Y, Chen K, Liu T, Lu J, Zhou Y, Guo C. Effects of Omega-3 Fatty Acid in Nonalcoholic Fatty Liver Disease: A Meta-Analysis. Gastroenterol Res Pract. 2016;2016:1459790. doi: 10.1155/2016/1459790. Epub 2016 Aug 29. FULL TEXT

Linecker M, Limani P, Kambakamba P, Kron P, Tschuor C, Calo N, Foti M, Dufour JF, Graf R, Humar B, Clavien PA. Omega-3 Fatty Acids Protect Fatty and Lean Mouse Livers After Major Hepatectomy. Ann Surg. 2016 Aug 25. [Epub ahead of print]

Ravi Kanth VV, Sasikala M, Sharma M, Rao PN, Reddy DN. Genetics of non-alcoholic fatty liver disease: From susceptibility and nutrient interactions to management. World J Hepatol. 2016 Jul 18;8(20):827-37. doi: 10.4254/wjh.v8.i20.827. FULL TEXT

Gong Y, Liu Z, Liao Y, Mai C, Chen T, Tang H, Tang Y. Effectiveness of ω-3 Polyunsaturated Fatty Acids Based Lipid Emulsions for Treatment of Patients after Hepatectomy: A Prospective Clinical Trial. Nutrients. 2016 Jun 17;8(6). pii: E357. doi: 10.3390/nu8060357. FULL TEXT

Li L, Wang B, Yu P et al. Medium and Long Chain Fatty Acids Differentially Modulate Apoptosis and Release of Inflammatory Cytokines in Human Liver Cells. J Food Sci. 2016 Jun;81(6):H1546-52. doi: 10.1111/1750-3841.13321. Epub 2016 May 3.

Valenzuela R, Espinosa A, Llanos P, Hernandez-Rodas MC, Barrera , Vergara D, Romero N, Pérez F, Ruz M, Videla LA. Anti-steatotic effects of an n-3 LCPUFA and extra virgin olive oil mixture in the liver of mice subjected to high-fat diet. Food Funct. 2015 Oct 16.

Nobili V , Alisi A , Musso G , Scorletti E , Calder PC , Byrne CD. Omega-3 fatty acids: Mechanisms of benefit and therapeutic effects in pediatric and adult NAFLD. Crit Rev Clin Lab Sci. 2015 Oct 14:1-15.

Nobili V , Alisi A , Musso G , Scorletti E , Calder PC , Byrne CD. Omega-3 fatty acids: Mechanisms of benefit and therapeutic effects in pediatric and adult NAFLD. Crit Rev Clin Lab Sci. 2015 Oct 14:1-15.

Linecker M, Limani P, Botea F, Popescu I, Alikhanov R, Efanov M, Kim P, Khatkov I, Raptis DA, Tschuor C, Beck-Schimmer B, Bonvini J, Wirsching A, Kron P, Slankamenac K, Humar B, Graf R, Petrowsky H, Clavien PA. A randomized, double-blind study of the effects of omega-3 fatty acids (Omegaven™) on outcome after major liver resection. BMC Gastroenterol. 2015 Aug 14;15:102 FULL TEXT

Scorletti E, West AL, Bhatia L, Hoile SP, McCormick KG, Burdge GC, Lillycrop KA, Clough GF, Calder PC, Byrne CD. Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: results from the WELCOME trial. J Hepatol. 2015 Aug 10. pii: S0168-8278(15)00539-5. doi: 10.1016/j.jhep.2015.07.036.

Nishiokada A, Miyoshi M, Fujiwara M, Aoyama-Ishikawa M, Maeshige N, Takahashi M, Hamada Y, Usami Y, Honda M, Arita M, Usami M. Changes of hepatic lipid mediators associated with intake of high-fat diet for 12 weeks in endotoxemic rats using LC-ESI-MS/MS. Clin Nutr. 2015 Aug;34(4):685-93.

Harris TR, Bettaieb A, Kodani S, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol. 2015 Jul 15;286(2):102-11.

Janczyk W, Lebensztejn D, Wierzbicka-Rucińska A3, Mazur A, Neuhoff-Murawska J, Matusik P, Socha P. Omega-3 Fatty acids therapy in children with nonalcoholic Fatty liver disease: a randomized controlled trial. J Pediatr. 2015 Jun;166(6):1358-63.e1-3.

Kabel AM, Abd Elmaaboud MA, Albarraq AA. Ameliorative potential of omega 3 fatty acids and HMG-CoA reductase inhibitors on experimentally-induced non-alcoholic steatohepatitis. Prostaglandins Leukot Essent Fatty Acids. 2015 May;96:1-9. doi: 10.1016/j.plefa.2014.12.003.

Janczyk W, Lebensztejn D, Wierzbicka-Rucińska A, Mazur A, Neuhoff-Murawska J, Matusik P, Socha P. Omega-3 Fatty Acids Therapy in Children with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial. J Pediatr. 2015 Mar 11. pii: S0022-3476(15)00103-1. doi: 10.1016/j.jpeds.2015.01.056.

Hospital and surgical environment

Yu J, Liu L, Zhang Y et al. Effects of omega-3 fatty acids on patients undergoing surgery for gastrointestinal malignancy: a systematic review and meta-analysis. BMC Cancer. 2017 Apr 14;17(1):271. FULL TEXT

Baldursson BT, Kjartansson H, Konrádsdóttir F, Gudnason P, Sigurjonsson GF, Lund SH. Healing Rate and Autoimmune Safety of Full-Thickness Wounds Treated With Fish Skin Acellular Dermal Matrix Versus Porcine Small-Intestine Submucosa: A Noninferiority Study. Int J Low Extrem Wounds. 2015 Mar 9. pii: 1534734615573661.

Basili S, Raparelli V, Napoleone L, Del Ben M, Merli M, Riggio O, Nocella C, Carnevale R, Pignatelli P, Violi F; on behalf of the CALC Group. Polyunsaturated fatty acids balance affects platelet NOX2 activity in patients with liver cirrhosis. Dig Liver Dis. 2014 Apr 1. pii: S1590-8658(14)00274-6.

Myhrstad MC, Ulven SM, Günther CC, Ottestad I, Holden M, Ryeng E, Borge GI, Kohler A, Brønner KW, Thoresen M, Holven KB. Fish oil supplementation induces expression of genes related to cell cycle, endoplasmic reticulum stress and apoptosis in peripheral blood mononuclear cells: a transcriptomic approach. J Intern Med. 2014 Mar 18. doi: 10.1111/joim.12217. [Epub ahead of print]

Kes VB, Cesarik M, Matovina LZ, Zavoreo I, Corić L, Drnasin S, Demarin V. The role of complementary and alternative medicine in therapy of multiple sclerosis. Acta Clin Croat. 2013 Dec;52(4):464-71.

Virtanen JK, Siscovick DS, Lemaitre RN et al. Circulating omega-3 polyunsaturated Fatty acids and subclinical brain abnormalities on MRI in older adults: the cardiovascular health study. J Am Heart Assoc. 2013 Oct 10;2(5):e000305.

Siasos G, Tousoulis D, Oikonomou E et al. Effects of omega-3 fatty acids on endothelial function, arterial wall properties, inflammatory and fibrinolytic status in smokers: a cross over study. Int J Cardiol. 2013 Jun 20;166(2):340-6.

Kurihara T, Jones CN, Yu YM et al. Resolvin D2 restores neutrophil directionality and improves survival after burns. FASEB J. 2013 Jun;27(6):2270-81.

Tipton KD. Dietary strategies to attenuate muscle loss during recovery from injury. Nestle Nutr Inst Workshop Ser 2013;75:51-61.

Sabbatini M1, Apicella L, Cataldi M, Maresca I, Nastasi A, Vitale S, Memoli B, Postiglione L, Riccio E, Gallo R, Federico S, Guida B. Effects of a diet rich in N-3 polyunsaturated fatty acids on systemic inflammation in renal transplant recipients. J Am Coll Nutr. 2013;32(6):375-83.

Lee SM, An WS. Cardioprotective effects of ? -3 PUFAs in chronic kidney disease. Biomed Res Int. 2013;2013:712949.

Bohr S, Patel SJ, Sarin D et al. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. Wound Repair Regen. 2013 Jan-Feb;21(1):35-43.

Wang T, Van KC, Gavitt BJ et al. Effect of fish oil supplementation in a rat model of multiple mild traumatic brain injuries. Restor Neurol Neurosci. 2013 Jan 1;31(5):647-59.

Mozaffarian D, Lemaitre RN, King IB, Song X, Huang H, Sacks FM, Rimm EB, Wang M, Siscovick DS. Plasma phospholipid long-chain omega-3 fatty acids and total and cause-specific mortality in older adults: a cohort study. Ann Intern Med. 2013; 158:515-525.

Hsiao HM, Sapinoro RE, Thatcher TH et al. A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. PLoS One. 2013;8(3):e58258.

Stanley WC, Khairallah RJ, Dabkowski ER. Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids. Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):122-6. doi: 10.1097/MCO.0b013e32834fdaf7.

Rius B, López-Vicario C, González-Périz A, Morán-Salvador E, García-Alonso V, Clária J, TitosE. Resolution of inflammation in obesity-induced liver disease. Front Immunol. 2012; 3: 257.

Taha AY, Ciobanu FA, Saxena A, McIntyre Burnham W. Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy. Epilepsy Behav. 2009 Jan;14(1):27-31. Epub 2008 Dec 2.

Wound healing

Male infertility

Martínez-Soto JC, Domingo JC, Cordobilla B, Nicolás M, Fernández L, Albero P, Gadea J, Landeras J. Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation. Syst Biol Reprod Med. 2016 Dec;62(6):387-395.

de Luis DA, Izaola O, Cuellar L et al. Clinical effects of a w3 enhanced powdered nutritional formula in postsurgical ambulatory head and neck cancer patients. Nutr Hosp. 2013 Septiembre-Octubre;28(5):1463-1467.

Terrando N, Gómez-Galán M, Yang T, Carlström M, Gustavsson D, Harding RE, Lindskog M, Eriksson LI. Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. FASEB J 2013; May 24.

Marsman HA, de Graaf W, Heger M et al. Hepatic regeneration and functional recovery following partial liver resection in an experimental model of hepatic steatosis treated with omega-3 fatty acids. Br J Surg. 2013 Apr;100(5):674-83.

Tipton KD. Dietary strategies to attenuate muscle loss during recovery from injury. Nestle Nutr Inst Workshop Ser 2013;75:51-61.

Philipson TJ, Snider JT, Lakdawalla DN et al. Impact of oral nutritional supplementation on hospital outcomes. Am J Manag Care 2013;19(2):121-128.

Kenchegowda S, He J, Bazan HE. Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):27-31.

Cortina MS, He J, Li N et al. Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery. Arch Ophthalmol. 2012 Jan;130(1):76-83.

Zhu MW, Tang DN, Hou J et al. Impact of fish oil enriched total parenteral nutrition on elderly patients after colorectal cancer surgery. Chin Med J (Engl). 2012 Jan;125(2):178-81.

Safarinejad MR, Safarinejad S. The roles of omega-3 and omega-6 fatty acids in idiopathic male infertility. Asian J Androl 2012;14(4):514-515.

van der Meij BS, van Bokhorst-de van der Schueren MA, Langius JA et al. n-3 PUFAs in cancer, surgery, and critical care: a systematic review on clinical effects, incorporation, and washout of oral or enteral compared with parenteral supplementation. Am J Clin Nutr. 2011 Nov;94(5):1248-1265.

Grau Carmona T, López Martínez J, Vila García B; Metabolism and Nutrition Working Group of the Spanish Society of Intensive Care Medicine and Coronary units. Guidelines for specialized nutritional and metabolic support in the critically-ill patient: update. Consensus SEMICYUC-SENPE: respiratory failure. Nutr Hosp. 2011 Nov;26 Suppl 2:37-40.

Klek S, Kulig J, Szczepanik AM, Jedrys J, Kolodziejczyk P. The clinical value of parenteral immunonutrition in surgical patients. Acta Chir Belg 2005;105:175-1791

Monoglycerides

Sepsis

Chen H, Wang W, Hong C, et al. Omega-3 Fish Oil Reduces Mortality Due to Severe Sepsis with Acute Gastrointestinal Injury Grade III. Pharmacogn Mag. 2017 Jul-Sep;13(51):407-12. FULL TEXT

Diaz LA, Altman NH, Khan W, Serhan CN, Adkins B. Specialized Pro-resolving Mediators (SPM) Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Re-infection. Infect Immun. 2017 Jul 10. [Epub ahead of print]

Buechler C, Pohl R, Aslanidis C. Pro-Resolving Molecules-New Approaches to Treat Sepsis? Int J Mol Sci. 2017 Feb 23;18(3). FULL TEXT

Xia H, Chen L, Liu H et al. Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype. Sci Rep. 2017 Dec;7(1):99. FULL TEXT

Husson MO, Ley D, Portal C, Gottrand M, Hueso T, Desseyn JL, Gottrand F. Modulation of host defence against bacterial and viral infections by omega-3 polyunsaturated fatty acids. J Infect. 2016 Dec;73(6):523-535.

Tao W, Li PS, Shen Z, Shu YS, Liu S. Effects of omega-3 fatty acid nutrition on mortality in septic patients: a meta-analysis of randomized controlled trials. BMC Anesthesiol. 2016 Jul 18;16(1):39. doi: 10.1186/s12871-016-0200-7. FULL TEXT

Hall TC, Bilku DK, Neal CP, Cooke J, Fisk HL, Calder PC, Dennison AR. The impact of an omega-3 fatty acid rich lipid emulsion on fatty acid profiles in critically ill septic patients. Prostaglandins Leukot Essent Fatty Acids. 2016 Sep;112:1-11. doi: 10.1016/j.plefa.2016.07.001. Epub 2016 Jul 14.

Svahn SL, Ulleryd MA, Grahnemo L et al. Dietary omega-3 fatty acids increase survival and decrease bacterial load in mice subjected to S. aureus-induced sepsis. Infect Immun. 2016 Feb 8. pii: IAI.01391-15. [Epub ahead of print]

Sickle cell disease

Kalish BT, Matte A, Andolfo I, Iolascon A, Weinberg O, Ghigo A, Cimino J, Siciliano A, Hirsch E, Federti E, Puder M, Brugnara C, De Franceschi L. Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease. Haematologica. 2015 Jul;100(7):870-80. FULL TEXT

Daak AA, Elderdery AY, Elbashir LM, Mariniello K, Mills J, Scarlett G, Elbashir MI, Ghebremeskel K. Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease. Blood Cells Mol Dis. 2015 Jun;55(1):48-55.

Daak AA, Elderdery AY, Elbashir LM, Mariniello K, Mills J, Scarlett G, Elbashir MI, Ghebremeskel K. Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease. Blood Cells Mol Dis. 2015 Jun;55(1):48-55. doi: 10.1016/j.bcmd.2015.03.014.

Kalish BT, Matte A, Andolfo I, Iolascon A, Weinberg O, Ghigo A, Cimino J, Siliciano A, Hirsch E, Federti E, Puder M, Brugnara C, De Franceschi L. Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease. Haematologica. 2015 May 1. pii: haematol.2015.124586.

Wandersee NJ, Maciaszek JL, Giger KM, Hanson MS, Zheng S, Guo Y, Mickelson B, Hillery CA, Lykotrafitis G, Low PS, Hogg N. Dietary supplementation with docosahexanoic acid (DHA) increases red blood cell membrane flexibility in mice with sickle cell disease. Blood Cells Mol Dis. 2015 Feb;54(2):183-8. doi: 10.1016/j.bcmd.2014.11.004. Epub 2014 Nov 25.

Okpala I, Ibegbulam O, Duru A, Ocheni S, Emodi I, Ikefuna A, Umar G, Asinobi I, Madu A, Okoye A, Nwagha T, Oguonu U, Uamai I, Agwu O, Nonyelu C, Anike U, Agu K, Anigbo C, Chukwura A, Ugwu O, Herrada S. Pilot study of omega-3 fatty acid supplements in sickle cell disease. APMIS. 2011 Jul;119(7):442-8. doi: 10.1111/j.1600-0463.2011.02751.x.

Traumatic Brain Injury

Tuberculosis

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