Studies

Metabolism

Diabetes

Ebrahimi FA, Samimi M, Foroozanfard F et al. The Effects of Omega-3 Fatty Acids and Vitamin E Co-Supplementation on Indices of Insulin Resistance and Hormonal Parameters in Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Exp Clin Endocrinol Diabetes. 2017 Apr 13.


Yorek MA. Is Fish Oil a Potential Treatment for Diabetic Peripheral Neuropathy? Curr Diabetes Rev. 2017 May 22.


Bi X, Li F, Liu S et al. ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity. J Clin Invest. 2017 May 1;127(5):1757-1771. FULL TEXT


Lewis EJH, Perkins BA, Lovblom LE et al. Effect of omega-3 supplementation on neuropathy in type 1 diabetes: A 12-month pilot trial. Neurology. 2017 May 17.


Behl T, Kotwani A. Omega-3 fatty acids in prevention of diabetic retinopathy. J Pharm Pharmacol. 2017 May 8. FULL TEXT


Cadario F, Savastio S, Rizzo AM et al. Can Type 1 diabetes progression be halted? Possible role of high dose vitamin D and omega 3 fatty acids. Eur Rev Med Pharmacol Sci. 2017 Apr;21(7):1604-1609. FULL TEXT


Yin Y, Chen F, Wang W et al. Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway. Mol Vis. 2017 Apr 14;23:242-250. eCollection 2017. FULL TEXT


Jamilian M, Samimi M, Ebrahimi FA et al. The effects of vitamin D and omega-3 fatty acid co-supplementation on glycemic control and lipid concentrations in patients with gestational diabetes. J Clin Lipidol. 2017 Mar - Apr;11(2):459-468.


Chauhan S, Kodali H, Noor J et al. Role of Omega-3 Fatty Acids on Lipid Profile in Diabetic Dyslipidaemia: Single Blind, Randomised Clinical Trial. J Clin Diagn Res. 2017 Mar;11(3):OC13-OC16. FULL TEXT


Ghadge AA, Kuvalekar AA. Controversy of oral hypoglycemic agents in type 2 diabetes mellitus: Novel move towards combination therapies. Diabetes Metab Syndr. 2016 Aug 22. pii: S1871-4021(16)30143-6. doi: 10.1016/j.dsx.2016.08.009. [Epub ahead of print]


Sala-Vila A, Díaz-López A, Valls-Pedret C, Cofán M, García-Layana A, Lamuela-Raventós RM, Castañer O, Zanon-Moreno V, Martinez-Gonzalez MA, Toledo E, Basora J, Salas-Salvadó J, Corella D, Gómez-Gracia E, Fiol M, Estruch R, Lapetra J, Fitó M, Arós F, Serra-Majem L, Pintó X, Ros E; Prevención con Dieta Mediterránea (PREDIMED) Investigators. Dietary Marine ω-3 Fatty Acids and Incident Sight-Threatening Retinopathy in Middle-Aged and Older Individuals With Type 2 Diabetes: Prospective Investigation From the PREDIMED Trial. JAMA Ophthalmol. 2016 Aug 18. doi: 10.1001/jamaophthalmol.2016.2906. [Epub ahead of print]


Graciano MF, Leonelli M, Curi R, R Carpinelli A. Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells. J Physiol Biochem. 2016 Jul 29. [Epub ahead of print]


Baidal DA, Ricordi C, Garcia-Contreras M, Sonnino A, Fabbri A. Combination high-dose omega-3 fatty acids and high-dose cholecalciferol in new onset type 1 diabetes: a potential role in preservation of beta-cell mass. Eur Rev Med Pharmacol Sci. 2016 Jul;20(15):3313-8. FULL TEXT


Okada K, Kotani K, Ishibashi S. Ankle-brachial index and eicosapentaenoic acid/arachidonic acid ratio in smokers with type 2 diabetes mellitus. Tob Induc Dis. 2016 Jan 28;14:2. doi: 10.1186/s12971-016-0068-9. eCollection 2016. FULL TEXT


Radosinska J, Kurahara LH, Hiraishi K, Viczenczova C, Egan Benova T, Bacova B, Dosenko V, Navarova J, Obsitnik B, Imanaga I, Soukup T, Tribulova N. Modulation of cardiac connexin-43 by omega-3 fatty acid ethyl-ester supplementation demonstrated in spontaneously diabetic rats. Physiol Res. 2015 Oct 8.


Kim H, Park S, Yang H, Choi YJ, Huh KB, Chang N. Association between fish and shellfish, and omega-3 PUFAs intake and CVD risk factors in middle-aged female patients with type 2 diabetes. Nutr Res Pract. 2015 Oct;9(5):496-502. FULL TEXT


Heemskerk MM, Giera M, Bouazzaoui FE, Lips MA, Pijl H, van Dijk KW, van Harmelen V. Increased PUFA Content and 5-Lipoxygenase Pathway Expression Are Associated with Subcutaneous Adipose Tissue Inflammation in Obese Women with Type 2 Diabetes. Nutrients. 2015 Sep 11;7(9):7676-90. FULL TEXT


Hassan A, Tajuddin N, Shaikh A. Retrospective Case Series of Patients with Diabetes or Prediabetes Who Were Switched from Omega-3-Acid Ethyl Esters to Icosapent Ethyl. Cardiol Ther. 2015 Jun;4(1):83-93. doi: 10.1007/s40119-014-0032-9. FULL TEXT


Capel F, Acquaviva C, Pitois E, Laillet B, Rigaudière JP, Jouve C, Pouyet C, Gladine C, Comte B, Vianey Saban C, Morio B. DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation. J Nutr Biochem. 2015 May 11. pii: S0955-2863(15)00102-3. doi: 10.1016/j.jnutbio.2015.04.003.


Capel F, Acquaviva C, Pitois E, Laillet B, Rigaudière JP, Jouve C, Pouyet C, Gladine C, Comte B, Vianey Saban C, Morio B. DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation. J Nutr Biochem. 2015 May 11. pii: S0955-2863(15)00102-3. doi: 10.1016/j.jnutbio.2015.04.003.


Jamilian M, Samimi M, Kolahdooz F, Khalaji F, Razavi M, Asemi Z. Omega-3 fatty acid supplementation affects pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial. J Matern Fetal Neonatal Med. 2015 Mar 9:1-7.


Herrera BS, Hasturk H, Kantarci A, Freire MO, Nguyen O, Kansal S, Van Dyke TE. Impact of resolvin E1 on murine neutrophil phagocytosis in type 2 diabetes. Infect Immun. 2015 Feb;83(2):792-801. doi: 10.1128/IAI.02444-14.


Yessoufou A, Nekoua MP, Gbankoto A, Mashalla Y, Moutairou K. Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity. J Diabetes Res. 2015;2015:731434. FULL TEXT


White PJ, St-Pierre P, Charbonneau A, Mitchell PL, St-Amand E, Marcotte B, Marette A. Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. Nat Med. 2014 May 11. doi: 10.1038/nm.3549. [Epub ahead of print]


Chung HF, Long KZ, Hsu CC, Al Mamun A, Jhang HR, Shin SJ, Hwang SJ, Huang MC. Association of n-3 polyunsaturated fatty acids and inflammatory indicators with renal function decline in type 2 diabetes. Clin Nutr. 2014 Mar 19. pii: S0261-5614(14)00071-5.


Aslan M, Ozcan F, Aslan B et al. LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy. Lipids Health Dis. 2013 Nov 6;12(1):169. FULL TEXT


Virtanen JK, Mursu J, Voutilainen S et al. Serum Omega-3 Polyunsaturated Fatty Acids and Risk of Incident Type 2 Diabetes in Men: The Kuopio Ischaemic Heart Disease Risk Factor Study. Diabetes Care. 2013 Sep 11.


Udupa A, Nahar P, Shah S et al. A comparative study of effects of omega-3 fatty acids, alpha lipoic acid and vitamin E in type 2 diabetes mellitus. Ann Med Health Sci Res. 2013 Jul-Sep; 3(3):442-446. FULL TEXT


Hajianfar H, Paknahad Z, Bahonar A. The effect of omega-3 supplements on antioxidant capacity in patients with type 2 diabetes. Int J Prev Med. 2013 May;4(Suppl 2):S234-8. FULL TEXT


Hajianfar H, Paknahad Z, Bahonar A. The effect of omega-3 supplements on antioxidant capacity in patients with type 2 diabetes. Int J Prev Med. 2013 May;4(Suppl 2):S234-8. FULL TEXT


Tang Y, Zhang MJ, Hellmann J et al. Proresolution therapy for the treatment of delayed healing of diabetic wounds. Diabetes. 2013 Feb;62(2):618-27. FULL TEXT


Martín de Santa Olalla L, Sánchez Muniz FJ, Vaquero MP. N-3 fatty acids in glucose metabolism and insulin sensitivity. Nutr Hosp. 2009 Mar-Apr;24(2):113-27. FULL TEXT


Shidfar F, Keshavarz A, Hosseyni S et al. Effects of omega-3 fatty acid supplements on serum lipids, apolipoproteins and malondialdehyde in type 2 diabetes patients. East Mediterr Health J. 2008 Mar-Apr;14(2):305-313.


West SG, Hecker KD, Mustad VA, Nicholson S, Schoemer SL, Wagner P, Hinderliter AL, Ulbrecht J, Ruey P, Kris-Etherton PM. Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes. Diabetologia. 2005 Jan;48(1):113-22. Epub 2004 Dec 29.

Metabolyc Syndrome

Obesity

JafariNasabian P, Inglis JE, Kelly OJ, Ilich JZ. Osteosarcopenic obesity in women: impact, prevalence, and management challenges. Int J Womens Health. 2017 Jan 13;9:33-42. FULL TEXT


Pahlavani M, Razafimanjato F, Ramalingam L, Kalupahana NS, Moussa H, Scoggin S, Moustaid-Moussa N. Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes. J Nutr Biochem. 2017 Jan;39:101-109. FULL TEXT


Zhang YY, Liu W, Zhao TY, Tian HM. Efficacy of Omega-3 Polyunsaturated Fatty Acids Supplementation in Managing Overweight and Obesity: A Meta-Analysis of Randomized Clinical Trials. J Nutr Health Aging. 2017;21(2):187-192.


Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond). 2016 Dec 13. doi: 10.1038/ijo.2016.211. [Epub ahead of print]


Cahyaningrum F, Permadhi I, Ansari MR, Prafiantini E, Rachman PH, Agustina R. Dietary optimisation with omega-3 and omega-6 fatty acids for 12-23-month-old overweight and obese children in urban Jakarta. Asia Pac J Clin Nutr. 2016 Dec;25(Suppl 1):S62-S74. FULL TEXT


Abbott KA, Burrows TL, Thota RN, Acharya S, Garg ML. Do ω-3 PUFAs affect insulin resistance in a sex-specific manner? A systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2016 Sep 28. pii: ajcn138172. [Epub ahead of print]


de Sá RD, Crisma AR, Cruz MM, Martins AR, Masi LN, do Amaral CL, Curi R, Alonso-Vale MI. Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes. J Physiol. 2016 Aug 25. doi: 10.1113/JP272541. [Epub ahead of print]


Simopoulos A. The FTO Gene, Browning of Adipose Tissue and Omega-3 Fatty Acids. J Nutrigenet Nutrigenomics. 2016 Aug 20;9(2-4):123-126. [Epub ahead of print] FULL TEXT


Polus A, Zapala B, Razny U, Gielicz A, Kiec-Wilk B, Malczewska-Malec M, Sanak M, Childs CE, Calder PC, Dembinska-Kiec A. Omega-3 fatty acid supplementation influences the whole blood transcriptome in women with obesity, associated with pro-resolving lipid mediator production. Biochim Biophys Acta. 2016 Aug 12;1861(11):1746-1755. doi: 10.1016/j.bbalip.2016.08.005. [Epub ahead of print]


Del Bas JM, Caimari A, Rodriguez-Naranjo MI, Childs CE, Paras Chavez C, West AL, Miles EA, Arola L, Calder PC. Impairment of lysophospholipid metabolism in obesity: altered plasma profile and desensitization to the modulatory properties of n-3 polyunsaturated fatty acids in a randomized controlled trial. Am J Clin Nutr. 2016 Aug;104(2):266-79. doi: 10.3945/ajcn.116.130872. Epub 2016 Jun 15.


Rafiee M, Sotoudeh G, Djalali M et al. Dietary ω-3 polyunsaturated fatty acid intake modulates impact of Insertion/Deletion polymorphism of ApoB gene on obesity risk in type 2 diabetic patients. Nutrition. 2016 Mar 25. pii: S0899-9007(16)30004-1. doi: 10.1016/j.nut.2016.03.012. [Epub ahead of print]


Simopoulos AP. An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity. Nutrients. 2016 Mar 2;8(3). pii: E128. doi: 10.3390/nu8030128. FULL TEXT


Simopoulos AP. An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity. Nutrients. 2016 Mar 2;8(3). pii: E128. doi: 10.3390/nu8030128. FULL TEXT


Mansoori A, Sotoudeh G, Djalali M et al. Docosahexaenoic Acid-Rich Fish Oil Supplementation Improves Body Composition without Influence of the PPARx03B3; Pro12Ala Polymorphism in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutrigenet Nutrigenomics. 2016 Feb 3;8(4-6):195-204. [Epub ahead of print]


Lopategi A, López-Vicario C, Alcaraz-Quiles J, García-Alonso V, Rius B, Titos E, Clària J. Role of bioactive lipid mediators in obese adipose tissue inflammation and endocrine dysfunction. Mol Cell Endocrinol. 2015 Nov 2. pii: S0303-7207(15)30099-X. doi: 10.1016/j.mce.2015.09.033. [Epub ahead of print]


Haghiac M, Yang XH, Presley L, Smith S, Dettelback S, Minium J, Belury MA, Catalano PM, Hauguel-de Mouzon S. Dietary Omega-3 Fatty Acid Supplementation Reduces Inflammation in Obese Pregnant Women: A Randomized Double-Blind Controlled Clinical Trial. PLoS One. 2015 Sep 4;10(9):e0137309. FULL TEXT


Ford NA, Rossi EL, Barnett K, Yang P, Bowers LW, Hidaka BH, Kimler BF, Carlson SE, Shureiqi I, deGraffenried LA, Fabian CJ, Hursting SD. Omega-3-Acid Ethyl Esters Block the Protumorigenic Effects of Obesity in Mouse Models of Postmenopausal Basal-like and Claudin-Low Breast Cancer. Cancer Prev Res (Phila). 2015 Sep;8(9):796-806.


Cardel M, Lemas DJ, Jackson KH, Friedman JE, Fernández JR. Higher Intake of PUFAs Is Associated with Lower Total and Visceral Adiposity and Higher Lean Mass in a Racially Diverse Sample of Children. J Nutr. 2015 Sep;145(9):2146-52.


Martínez-Fernández L, Laiglesia LM, Huerta AE, Martínez JA, Moreno-Aliaga MJ. Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome. Prostaglandins Other Lipid Mediat. 2015 Jul 26. pii: S1098-8823(15)30004-6. doi: 10.1016/j.p


Pavlisova J, Bardova K, Stankova B, Tvrzicka E, Kopecky J, Rossmeisl M. Corn oil versus lard: Metabolic effects of omega-3 fatty acids in mice fed obesogenic diets with different fatty acid composition. Biochimie. 2015 Jul 4. pii: S0300-9084(15)00209-6.


Yehuda S, Rabinovitz S. The Role of Essential Fatty Acids in Anorexia Nervosa and in Obesity. Crit Rev Food Sci Nutr. 2015 Jun 11:0.


Im DS. Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages. Eur J Pharmacol. 2015 May 15. pii: S0014-2999(15)00458-6. doi:10.1016/j.ejphar.2015.03.094.


Belchior T, Paschoal VA, Magdalon J, Chimin P, Farias TM, Chaves-Filho AB, Gorjão R, St-Pierre P, Miyamoto S, Kang JX, Deshaies Y, Marette A, Festuccia W. Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ-dependent and PPARγ-independent actions. Mol Nutr Food Res. 2015 May;59(5):957-67. doi: 10.1002/mnfr.201400914.


Masoodi M, Kuda O, Rossmeisl M, Flachs P, Kopecky J. Lipid signaling in adipose tissue: Connecting inflammation & metabolism. Biochim Biophys Acta. 2015 Apr;1851(4):503-518. doi: 10.1016/j.bbalip.2014.09.023.


Choi SH, Choi-Kwon S. The effects of the DASH diet education program with omega-3 fatty acid supplementation on metabolic syndrome parameters in elderly women with abdominal obesity. Nutr Res Pract. 2015 Apr;9(2):150-7. doi: 10.4162/nrp.2015.9.2.150. FULL TEXT


LeMieux MJ, Kalupahana NS, Scoggin S, Moustaid-Moussa N. “Eicosapentaenoic Acid reduces adipocyte hypertrophy and inflammation in diet-induced obese mice in an adiposity-independent manner." J Nutr. 2015 Mar;145(3):411-7. doi: 10.3945/jn.114.202952.


White PJ, Mitchell PL, Schwab M, Trottier J, Kang JX, Barbier O, Marette A. Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins. Metabolism. 2015 Feb 3. pii: S0026-0495(15)00036-0. Doi:10.1016/j.metabol.2015.01.017.


Huerta AE, Navas-Carretero S, Prieto-Hontoria PL, Martínez JA, Moreno-Aliaga MJ. “Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. Obesity (Silver Spring). 2015 Feb;23(2):313-21. doi: 10.1002/oby.20966.


López-Vicario C, Alcaraz-Quiles J, García-Alonso V, Rius B, Hwang SH, Titos E, Lopategi A, Hammock BD, Arroyo V, Clària J. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides. Proc Natl Acad Sci U S A. 2014 Dec 30. pii: 201422590. FULL TEXT


Howe PR, Buckley JD, Murphy KJ, Pettman T, Milte C, Coates AM. Relationship between erythrocyte omega-3 content and obesity is gender dependent. Nutrients. 2014 May 5;6(5):1850-60. doi: 10.3390/nu6051850. FULL TEXT


Periyalil HA, Gibson PG, Wood LG. Immunometabolism in obese asthmatics: are we there yet? Nutrients. 2013 Sep 10;5(9):3506-3530. FULL TEXT


Joffe YT, Collins M, Goedecke JH. The relationship between dietary fatty acids and inflammatory genes on the obese phenotype and serum lipids. Nutrients. 2013 May 21;5(5):1672-1705. FULL TEXT


Browning LM. n-3 Polyunsaturated fatty acids, inflammation and obesity-related disease. Proc Nutr Soc. 2003 May;62(2):447-53.


Rius B, López-Vicario C, González-Périz A, Morán-Salvador E, García-Alonso V, Clária J, TitosE. Resolution of inflammation in obesity-induced liver disease. Front Immunol. 2012; 3: 257. FULL TEXT


Dangardt F, Osika W, Chen Y et al. Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents. Atherosclerosis. 2010 Oct;212(2):580-585.


Buckley JD, Howe PR. Long-chain omega-3 polyunsaturated fatty acids may be beneficial forreducing obesity-a review. Nutrients 2010;2(12):1212-1230. FULL TEXT


Itoh M, Suganami T, Satoh N, Tanimoto-Koyama K, Yuan X, Tanaka M, Kawano H, Yano T, Aoe S, Takeya M, Shimatsu A, Kuzuya H, Kamei Y, Ogawa Y. Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. Arterioscler Thromb Vasc Biol. 2007;27;1918-25. FULL TEXT


Recasens M, Ricart W, Fernández-Real JM. Obesidad e inflamación. Rev Med Univ Navarra. 2004;48(2):49-54.

Primary chylomicronemia

Systemic inflammatory processes

Navarro SL, Kantor ED, Song X et al. Factors Associated with Multiple Biomarkers of Systemic Inflammation. Cancer Epidemiol Biomarkers Prev. 2016 Mar;25(3):521-31. doi: 10.1158/1055-9965.EPI-15-0956. Epub 2016 Jan 11.


Espiritu MM, Lin H, Foley E et al. Omega-3 fatty acids modulate neonatal cytokine response to endotoxin. J Perinat Med. 2016 Jan 22. pii: /j/jpme.ahead-of-print/jpm-2015-0248/jpm-2015-0248.xml. doi: 10.1515/jpm-2015-0248. [Epub ahead of print]


Tamma SM, Shorter B, Toh KL, Moldwin R, Gordon B. Influence of polyunsaturated fatty acids on urologic inflammation. Int Urol Nephrol. 2015 Nov;47(11):1753-61.


Shikama Y, Kudo Y, Ishimaru N, Funaki M. Possible Involvement of Palmitate in Pathogenesis of Periodontitis. J Cell Physiol. 2015 Apr 29. doi: 10.1002/jcp.25029.


Calle D, Negri V, Ballesteros P, Cerdán S. Magnetoliposomes loaded with poly-unsaturated Fatty acids as novel theranostic anti-inflammatory formulations. Theranostics. 2015 Feb 15;5(5):489-503. doi: 10.7150/thno.10069.


Sabbatini M, Apicella L, Cataldi M, Maresca I, Nastasi A, Vitale S, Memoli B, Postiglione L, Riccio E, Gallo R, Federico S, Guida B. Effects of a diet rich in N-3 polyunsaturated fatty acids on systemic inflammation in renal transplant recipients. J Am Coll Nutr. 2013;32(6):375-83. doi: 10.1080/07315724.2013.826482.


Oz HS, Chen TS, Neuman M. Nutrition intervention: a strategy against systemic inflammatory syndrome. JPEN J Parenter Enteral Nutr. 2009 Jul-Aug;33(4):380-9. Epub 2009 Apr 14. FULL TEXT


Undurti N Das. Can essential fatty acids reduce the burden of disease(s)? Lipids Health Dis. 2008;7:9. FULL TEXT


Llor X. Papel de los lípidos de la dieta en los mecanismos de inflamación, proliferación, diferenciación y muerte celular en el tracto intestinal. Gastroenterol Hepatol. 2003;26:507-13. FULL TEXT