Studies

Inflammatory diseases

Inflammation

Michalak A, Mosińska P, Fichna J. Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer. Front Pharmacol. 2016 Dec 1;7:459. FULL TEXT


Ohashi W, Hattori K, Hattori Y. Control of Macrophage Dynamics as a Potential Therapeutic Approach for Clinical Disorders Involving Chronic Inflammation. J Pharmacol Exp Ther. 2015 Sep;354(3):240-50.


Calder PC. Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. Biochim Biophys Acta. 2015 Apr;1851(4):469-484. doi: 10.1016/j.bbalip.2014.08.010.


Chang HY, Lee HN, Kim W, Surh YJ. Docosahexaenoic acid induces M2 macrophage polarization through peroxisome proliferator-activated receptor γ activation. Life Sci. 2015 Jan 1;120:39-47. doi: 10.1016/j.lfs.2014.10.014.


Heemskerk MM, Dharuri HK, van den Berg SA, Jónasdóttir HS, Kloos DP, Giera M, van Dijk KW, van Harmelen V. Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile. J Lipid Res. 2014 Dec;55(12):2532-40. doi: 10.1194/jlr.M051938.


Cipollina C, Di Vincenzo S, Gerbino S, Siena L, Gjomarkaj M, Pace E. Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation. Biochim Biophys Acta. 2014 Mar 2. pii: S0304-4165(14)00085-3.


Ferguson JF, Mulvey CK, Patel PN et al. Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers. Mol Nutr Food Res. 2013 Nov 5. FULL TEXT


Yates CM, Calder PC, Ed Rainger G. Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease. Pharmacol Ther. 2013 Nov 4. pii: S0163-7258(13)00215-5.


Raphael W, Sordillo LM. Dietary polyunsaturated Fatty acids and inflammation: the role of phospholipid biosynthesis. Int J Mol Sci. 2013 Oct 22;14(10):21167-88. FULL TEXT


Alsaleh A, Crepostnaia D, Maniou Z et al. Adiponectin gene variant interacts with fish oil supplementation to influence serum adiponectin in older individuals. J Nutr. 2013 Jul;143(7):1021-7. FULL TEXT


Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? Br J Clin Pharmacol. 2013 Mar;75(3):645-662. FULL TEXT


Calder PC. Fatty acids and inflammation: the cutting edge between food and pharma. Eur J Pharmacol. 2011 Sep;668 Suppl 1:S50-8. doi: 10.1016/j.ejphar.2011.05.085. Epub 2011 Jul 28.


Skulas-Ray AC, Kris-Etherton PM, Harris WS et al. Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr. 2011 Feb;93(2):243-52. FULL TEXT


Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochim Biophys Acta. 2010 Dec;1801(12):1260-73. FULL TEXT


Massaro M, Scoditti E, Carluccio MA, Campana MC, De Caterina R. Omega-3 fatty acids, inflammation and angiogenesis: basic mechanisms behind the cardioprotective effects of fish and fish oils. Cell Mol Biol (Noisy-le-grand). 2010 Feb 25;56(1):59-82.


Seki H, Sasaki T, Ueda T et al. Resolvins as regulators of the immune system. ScientificWorldJournal 2010;10:818¬831. FULL TEXT


Bannenberg GL. Resolvins: Current understanding and future potential in the control of inflammation. Curr Opin Drug Discov Devel. 2009 Sep;12(5):644-58.


Massaro M, Scoditti E, Carluccio MA, Montinari MR, De Caterina R. Omega-3 fatty acids, inflammation and angiogenesis: nutrigenomic effects as an explanation for anti-atherogenic and anti-inflammatory effects of fish and fish oils. J Nutrigenet Nutrigenomics. 2008;1(1-2):4-23. Epub 2007 Oct 17. FULL TEXT


Sijben JW, Calder PC. Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. Proc Nutr Soc. 2007 May;66(2):237-59.


Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1505S-1519S. FULL TEXT


Mesa García MD, Aguilera García CM, Gil Hernández A. Importancia de los lípidos en el tratamiento nutricional de las patologías de base inflamatoria. Nutr Hosp. 2006;21(Suppl.2):30-43. FULL TEXT


Lee KW, Blann AD, Lip GY. Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction. Thromb Res. 2006;118(3):305-12. Epub 2005 Sep 8.


Kew S, Mesa MD, Tricon S, Buckley R, Minihane AM, Yaqoob P. Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans. Am J Clin Nutr. 2004 Apr;79(4):674-81. FULL TEXT


Calder PC. Dietary modification of inflammation with lipids. Proc Nutr Soc. 2002 Aug;61(3):345-58.


Thies F, Miles EA, Nebe-von-Caron G, Powell JR, Hurst TL, Newsholme EA, Calder PC. Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. Lipids. 2001 Nov;36(11):1183-93.

Inflammatory bowel disease

Bentley-Hewitt KL, De Guzman CE, Ansell J, Mandimika T, Narbad A, Lund EK. How fish oils could support our friendly bacteria. Lipid Technology. 2015 Aug;27(8):179–82.


Zhang R, He GZ, Wang YK, Zhou KG, Ma EL. Omega-3 polyunsaturated fatty acids inhibit the increase in cytokines and chemotactic factors induced in vitro by lymph fluid from an intestinal ischemia-reperfusion injury model. Nutrition. 2015 Mar;31(3):508-14. doi: 10.1016/j.nut.2014.10.015.


Marcon R, Bento AF, Dutra RC et al. Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis. J Immunol. 2013 Oct 15;191(8):4288-98. FULL TEXT


Mbodji K, Charpentier C, Guérin C et al. Adjunct therapy of n-3 fatty acids to 5-ASA ameliorates inflammatory score and decreases NF-?B in rats with TNBS-induced colitis. J Nutr Biochem. 2013 Apr;24(4):700-5.


Tabbaa M, Golubic M, Roizen MF et al. Docosahexaenoic Acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. Nutrients 2013;5(8):3299-3310. FULL TEXT


Bento AF, Claudino RF, Dutra RC et al. Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice. J Immunol. 2011 Aug 15;187(4):1957-69. FULL TEXT


Turner D, Shah PS, Steinhart AH, Zlotkin S, Griffiths AM. Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): A systematic review and meta-analyses. Inflamm Bowel Dis. 2010 Jun 17.


Uchiyama K, Nakamura M, Odahara S et al. N¬3 polyunsaturated fatty acid diet therapy for patients with inflammatory bowel disease. Inflamm Bowel Dis 2010;16:1696¬1707.


Ruggiero C, Lattanzio F, Lauretani F, Gasperini B, Andres-Lacueva C, Cherubini A. Omega-3 polyunsaturated fatty acids and immune-mediated diseases: inflammatory bowel disease and rheumatoid arthritis. Curr Pharm Des. 2009;15(36):4135-48.


Arrizabalaga JJ. Manejo nutricional de la enfermedad inflamatoria intestinal. Endocrinol Nutr. 2007;54:151-68. FULL TEXT


Trebble TM, Arden NK, Wootton SA, Calder PC, Mullee MA, Fine DR, Stroud MA. Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease. Am J Clin Nutr. 2004;80:1137-44. FULL TEXT


Llor X. Papel de los lípidos de la dieta en los mecanismos de inflamación, proliferación, diferenciación y muerte celular en el tracto intestinal. Gastroenterol Hepatol. 2003;26:507-13. FULL TEXT


Almallah YZ, El-Tahir A, Heys SD, Richardson S, Eremin O. Distal procto-colitis and n-3 polyunsaturated fatty acids: The mechanism(s) of natural cytotoxicity inhibition. Eur J Clin Invest. 2000;30:58-65.


Almallah YZ, Ewen SW, El-Tahir A, Mowat NA, Brunt PW, Sinclair TS, Heys SD, Eremin O. Distal proctocolitis and n-3 polyunsaturated fatty acids (n-3 PUFAs): the mucosal effect in situ. J Clin Immunol. 2000 Jan;20(1):68-76.


Almallah YZ, Richardson S, O'Hanrahan T, Mowat NA, Brunt PW, Sinclair TS, Ewen S, Heys SD, Eremin O. Distal procto-colitis, natural cytotoxicity, and essential fatty acids. Am J Gastroenterol. 1998;93:804-9.


Sharon P, Stenson WF. Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology. 1984;86:453-60.

Others

Periodontitis

Sun M, Zhou Z, Dong J, Zhang J, Xia Y, Shu R. Antibacterial and antibiofilm activities of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) against periodontopathic bacteria. Microb Pathog. 2016 Aug 24;99:196-203. doi: 10.1016/j.micpath.2016.08.025. [Epub ahead of print]


Woelber JP, Bremer K, Vach K, König D, Hellwig E, Ratka-Krüger P, Al-Ahmad A, Tennert C. An oral health optimized diet can reduce gingival and periodontal inflammation in humans - a randomized controlled pilot study. BMC Oral Health. 2016 Jul 26;17(1):28. doi: 10.1186/s12903-016-0257-1. FULL TEXT


Chee B, Park B, Fitzsimmons T et al. Omega-3 fatty acids as an adjunct for periodontal therapy-a review. Clin Oral Investig. 2016 Feb 17. [Epub ahead of print]


Dodington DW, Fritz PC, Sullivan PJ, Ward WE. Higher Intakes of Fruits and Vegetables, β-Carotene, Vitamin C, α-Tocopherol, EPA, and DHA Are Positively Associated with Periodontal Healing after Nonsurgical Periodontal Therapy in Nonsmokers but Not in Smokers. J Nutr. 2015 Sep 30.


Mustafa M, Zarrough A, Bolstad AI et al. Resolvin D1 protects periodontal ligament. Am J Physiol Cell Physiol. 2013 Sep;305(6):C673-9. FULL TEXT


Tabbaa M, Golubic M, Roizen MF et al. Docosahexaenoic Acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. Nutrients 2013;5(8):3299-3310. FULL TEXT


Elkhouli AM. The efficacy of host response modulation therapy (omega-3 plus low-dose aspirin) as an adjunctive treatment of chronic periodontitis (clinical and biochemical study). J Periodontal Res. 2011 Apr;46(2):261-8.


El-Sharkawy H, Aboelsaad N, Eliwa M et al. Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 fatty acids and low-dose aspirin. J Periodontol. 2010;81:1635-1643.

Rheumatoid arthritis

Huang J, Burston JJ, Li L, Ashraf S, Mapp PI, Bennett AJ, Ravipati S, Pousinis P, Barrett DA, Scammell BE, Chapman V. Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain. Arthritis Rheumatol. 2016 Nov 16. doi: 10.1002/art.40001. [Epub ahead of print]


Gan RW, Young KA, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Clare-Salzler MJ, Deane KD, Holers VM, Norris JM. Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study. Rheumatology (Oxford). 2015 Sep 13.


Souza PR, Norling LV. Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. Eur J Pharmacol. 2015 Jul 9. pii: S0014-2999(15)30148-5. doi: 10.1016/j.ejphar.2015.05.072.


Proudman SM, James MJ, Spargo LD et al. Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use. Ann Rheum Dis. Published online September 30, 2013.


Lee AL, Park Y. The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women. Ann Nutr Metab. 2013 Aug 14;63(1-2):88-95.


Norling LV, Perretti M. The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol. 2013 Jun;13(3):476-481.


Lee YH, Bae SC, Song GG. Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis. Arch Med Res. 2012 Jul;43(5):356-362.


Miles EA, Calder PC. Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis. Br J Nutr. 2012 Jun;107 Suppl 2:S171-84.


Gheita T, Kamel S, Helmy N et al. Omega-3 fatty acids in juvenile idiopathic arthritis: effect on cytokines (IL-1 and TNF-a), disease activity and response criteria. Clin Rheumatol. 2012 Feb;31(2):363-366.


Xu ZZ, Ji RR. Resolvins are potent analgesics for arthritic pain. Br J Pharmacol. 2011 Sep;164(2):274-277. FULL TEXT


James M, Proudman S, Cleland L. Fish oil and rheumatoid arthritis: past, present and future. Proc Nutr Soc. 2010 Aug;69(3):316-23.


Bahadori B, Uitz E, Thonhofer R, Trummer M, Pestemer-Lach I, McCarty M, Krejs GJ. omega-3 Fatty acids infusions as adjuvant therapy in rheumatoid arthritis. JPEN J Parenter Enteral Nutr. 2010 Mar-Apr;34(2):151-5.


Wann AK, Mistry J, Blain EJ et al. Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1ß-mediated cartilage degradation. Arthritis Res Ther. 2010;12(6):R207. FULL TEXT


Caughey GE, James MJ, Proudman SM et al. Fish oil supplementation increases the cyclo oxygenase inhibitory activity of paracetamol in rheumatoid arthritis patients. Complement Ther Med 2010;18:171¬174.


Hurst S, Zainal Z, Caterson B et al. Dietary fatty acids and arthritis. Prostaglandins Leukot Essent Fatty Acids 2010;82:315¬318.


Das Gupta AB, Hossain AK, Islam MH, Dey SR, Khan AL. Role of omega-3 fatty acid supplementation with indomethacin in suppression of disease activity in rheumatoid arthritis. Bangladesh Med Res Counc Bull. 2009 Aug;35(2):63-8.


Ruggiero C, Lattanzio F, Lauretani F, Gasperini B, Andres-Lacueva C, Cherubini A. Omega-3 polyunsaturated fatty acids and immune-mediated diseases: inflammatory bowel disease and rheumatoid arthritis. Curr Pharm Des. 2009;15(36):4135-48.


Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain. 2007 May;129(1-2):210-223.


Leeb BF, Sautner J, Andel I, Rintelen B. Intravenous application of omega-3 fatty acids in patients with active rheumatoid arthritis. The ORA-1 trial. An open pilot study. Lipids. 2006 Jan;41(1):29-34.


Venkatraman JT, Chu WC. Effects of dietary omega-3 and omega-6 lipids and vitamin E on serum cytokines, lipid mediators and anti-DNA antibodies in a mouse model for rheumatoid arthritis. J Am Coll Nutr. 1999 Dec;18(6):602-13.


Ariza-Ariza R, Mestanza-Peralta M, Cardiel MH. Omega-3 fatty acids in rheumatoid arthritis: an overview. Semin Arthritis Rheum. 1998 Jun;27(6):366-70.


Geusens P, Wouters C, Nijs J, Jiang Y, Dequeker J. Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. A 12-month, double-blind, controlled study. Arthritis Rheum. 1994 Jun;37(6):824-9.


Kjeldsen-Kragh J, Lund JA, Riise T, Finnanger B, Haaland K, Finstad R, Mikkelsen K, Førre O. Dietary omega-3 fatty acid supplementation and naproxen treatment in patients with rheumatoid arthritis. J Rheumatol. 1992 Oct;19(10):1531-6.


Sperling RI. Dietary omega-3 fatty acids: effects on lipid mediators of inflammation and rheumatoid arthritis. Rheum Dis Clin North Am. 1991 May;17(2):373-89.


Kremer JM. Clinical studies of omega-3 fatty acid supplementation in patients who have rheumatoid arthritis. Rheum Dis Clin North Am. 1991 May;17(2):391-402.


Astorga G, Cubillos A, Masson L, Silva JJ. Active rheumatoid arthritis: effect of dietary supplementation with omega-3 oils. A controlled double-blind trial. Rev Med Chil. 1991 Mar;119(3):267-72.