Study on the efficacy of omega-3 supplementation on dry-eye syndrome
To assess whether supplementation with omega-3 fatty acids is more effective than placebo in improving the signs and symptoms of dry-eye syndrome, a systematic search of the literature was conducted using the PubMed, Scopus, Web of Science and Cochrane Central of Controlled Trials databases. The search included randomised clinical trials to compare omega-3 supplementation with placebo in patients with dry-eye syndrome. The outcomes analysed were dry-eye symptoms, break-up time, Schirmer’s test and corneal fluorescein staining. The analysis included 17 randomised clinical trials with 3363 patients. Compared to the placebo groups, omega-3 supplementation reduced the symptoms of dry eye and there were statistically significant differences in the changes in the fluorescein staining, while the increase in break-up time and Schirmer’s test values were also statistically significant. No evidence of publication bias was observed and the sensitivity analyses indicated the results were robust. The meta-regression analysis showed a greater improvement in dry-eye symptoms in the trials conducted in India.
This meta-analysis provides evidence that supplementation with omega-3 significantly improves the signs and symptoms of dry eye in patients with dry-eye syndrome. It also indicates that supplementation with omega-3 fatty acids could be an effective treatment for dry-eye syndrome.