Omega-3 and probiotics in the treatment of nonalcoholic fatty liver
Firstly, supplementation with omega-3 fatty acids (n-3 FAs) has been shown to have beneficial effects on the regulation of liver lipid metabolism, adipose tissue function and inflammation. Secondly, manipulating intestinal microbiota using probiotics could be a possible preventative treatment for nonalcoholic fatty liver disease (NAFLD). Based on these premises, Kobyliak et al. designed a study to assess whether the addition of n-3 FA to probiotics was better than the latter alone in treating NAFLD, using a mouse model monosodium glutamate-induced NAFLD.
Supplementation with live probiotics and n-3 FA produced a 20% greater reduction in fatty liver than supplementation with probiotics alone. Furthermore, the combination also produced a 16.6% greater drop in triglyceride concentrations than with probiotics alone. These results show a greater drop in fatty liver and liver lipid accumulation after treatment with n-3 FA and probiotics than after treatment administering just probiotics.
The researchers went on to reproduce these results in human clinical conditions.