Study Reviews

Joint administration of vitamin D and omega-3 FA has beneficial effects on women with polycystic ovary syndrome (PCOS)

  • 08/15/2018

Between 5 and 10% of women at reproductive age develop polycystic ovary syndrome (PCOS), which is caused by an imbalance in reproductive hormones. This hormone imbalance can cause amenorrhea or irregular menstrual cycles, which in turn can lead to infertility and the development of cysts in the ovaries.

Recently, a study was conducted in which 60 women aged 18 to 40 with PCOS were randomly assigned to receive 50,000 IU of vitamin D every 2 weeks plus 2,000  mg/day of omega-3 fatty acid (FA) in fish oil (n = 30) or placebo (n = 30) for 12 weeks. The results showed that, compared to placebo, joint administration of vitamin D and omega-3 FA: significantly reduced testosterone levels; significantly improved scores on the Beck Depression Inventory, on a general health questionnaire and on anxiety and health scales; significantly reduced levels of serum high-sensitivity C-reactive protein and malondialdehyde; and increased total plasma antioxidant capacity. It also down-regulated expression of interleukin-1 and up-regulated vascular endothelial growth factor in peripheral blood mononuclear cells.

Thus, joint administration of vitamin D and omega-3 FA showed beneficial effects in women with PCOS: improved hormone profile, improvement to metabolic abnormalities and endothelial dysfunction, and improvements in depression, anxiety and stress.

Jamilian M, Samimi M, Mirhosseini N, Afshar Ebrahimi F, Aghadavod E, Talaee R, et al. The influences of vitamin D and omega-3 co-supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome. J Affect Disord. 2018;238:32-38.

Office on Women’s Health. US Department of Health and Human Services      Polycystic ovary syndrome.