DHA has a neuroprotective effect in chronic alcoholism
In an oral communication at the European Society for Biomedical Research Congress on Alcoholism held this September in Warsaw, Michael A. Collins (Loyola University Chicago Stritch School of Medicine), suggested that Omega-3 from fish oil may be effective in preventing dementia associated with chronic alcoholism.
The researchers exposed cultures of rat brain cells to high levels of alcohol and compared them to brain cell cultures exposed to the same levels of alcohol plus docosahexaenoic acid (DHA). The results showed approximately 90% less neuroinflammation and neuronal death in the cultures that were also exposed to DHA. In brain organotypic cultures, sub-chronic exposure to high levels of ethanol triggers neuroinflammatory pathways leading to oxidative stress and regional neurodegeneration. Administration of Omega-3 DHA has a neuroprotective effect because it significantly reduces PARP1 (poly (ADP-ribose) polymerase-1), AQP4 (aquaporin-4) and PLA2 (phospholipase A2) increase, the release of AA (arachidonic acid) and nerve damage.